An efficient and experimentally straightforward method for the stereoselective synthesis of a variety of β-nitroα-amino carboxylic acids via aza-Henry (nitro-Mannich) reaction of aldimines is disclosed, yielding either anti-or a rarely reported syn-configuration. The reaction operates directly on free glyoxylic acid and generates imine species in situ. Crystallization-controlled diastereoselectivity enables isolation of the target compounds in high enantio-and diastereomeric purities by a simple filtration.
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