SUMMARY Endotoxins in plasma were monitored during treatment in 18 patients hospitalised for acute exacerbation of Crohn's disease: systemic endotoxaemia was found on admission in all but one. The patients were randomly divided into two groups: one receiving treatment with total parenteral nutrition and steroids. To decrease the absorbable endotoxin pool, the other group was additionally treated with whole gut irrigation and 5-aminosalicylic acid was added to the lavage fluid. In most of these patients endotoxaemia cleared after intestinal lavage and they needed shorter hospitalisation. Earlier improvement was also indicated by a faster decrease of the Crohn's disease activity index and vanHees index. In the group receiving conservative treatment alone, endotoxaemia was controlled within three weeks. We conclude that endotoxaemia occurs in most patients suffering from active Crohn's disease. Control of endotoxaemia after intestinal lavage suggests that systemic endotoxaemia is caused by absorption of endotoxins from the gut. Earlier improvement after whole gut irrigation indicates its beneficial effect in active Crohn's disease.
The amination of NaZSM-5 (only 3743 cm-l Si-OH groups) and of NaHZSM-5 zeolites (both 3743 cm-l Si-OH and 'bridged' Si-OH...Al 3609cm-I groups) has been studied at temperatures between 673 and 1073 K. The reaction with very dry ammonia results in the formation of Si-NH, and Si-NH;..Al groups, in which case the amination of 'bridged' Si-OH..-Al groups occurs at a lower temperature than that of Si-OH groups. At temperatures higher than 773 K NH, groups undergo further reaction (imination) resulting in the formation of Si-NH-Si and Si-NH-A1 groups. A mechanism of amination and imination has been proposed. NH, groups were generated by substitution of OH groups and in a dissociative reaction of ammonia with siloxane bridges or Si-0-A1 bridges. NH groups (silazane bridges) were formed by elimination of NH, from vicinal NH, groups.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.