BackgroundPolyphenols have received a great deal of attention due to their biological functions. Pomegranate (Punica granatum L.) is a polyphenol-rich fruit. In the past decade, studies testing the antimicrobial activity of pomegranates almost exclusively used solvent extracts instead of fresh pomegranate juice (FPJ). The use of FPJ instead of solvent extracts would reduce toxicity issues while increasing patient acceptance. We established a model to test FPJ as a natural antimicrobial agent.ObjectiveTo evaluate the antimicrobial activity of FPJ on clinical isolates of multidrug-resistant Staphylococcus epidermidis strains.DesignSixty strains of S. epidermidis isolated from ocular infections were grown in the presence of FPJ, and minimum inhibitory concentration (MIC) was determined by broth and agar dilution methods.ResultsFPJ at 20% had a MIC equal to 100% (MIC100%) on all 60 strains tested. This inhibition of FPJ was confirmed by the growth kinetics of a multidrug-resistant strain exposed to different concentrations of FPJ. Additionally, the antimicrobial activity of FPJ was compared against commercial beverages containing pomegranate: Ocean Spray® had a MIC100% at 20%, followed by Del Valle® with a MIC15% at 20% concentration only. The beverages Jumex® and Sonrisa® did not have any antimicrobial activity. FPJ had the highest polyphenol content and antioxidant capacity.ConclusionsOverall, FPJ had antimicrobial activity, which might be attributed to its high polyphenol content and antioxidant capacity.
Introduction: systemic arterial hypertension (SAH) is the main risk factor for the developing of cardiovascular disease, which the leading cause of death worldwide. One of the best ways to control blood pressure (BP) levels is the combination of lifestyle changes and drug therapy. However, pharmacotherapy is expensive and produces adverse reactions. Thus, it is necessary to find cheap, safe and effective alternative treatments. Hibiscus sabdariffa L. (HS) is a plant that is traditionally used in some countries to treat SAH, which has given rise to various investigations to determine their compounds and their antihypertensive activity. Aim: the present article aims at reviewing the reports that support the antihypertensive activity of extracts from HS in animal and human models Conclusions: the information collected from scientific literature suggests that HS extracts have antihypertensive effects in animals and humans, especially in early stages; however, more studies in advanced stages of hypertension are needed.
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