Herein we report new multiblock chalcone conjugate phthalimide and naphthalimide functionalized copolymers with a topologically novel architecture synthesis using nucleophilic substitution and polycondensation methodology. The structures of the synthesized novolacs were elucidated on the basis of their spectroscopic analysis including FTIR, 1H NMR, and 13C NMR spectroscopy. Further, the number-average and weight-average molecular weights of the novolac polymers were determined by gel permeation chromatography (GPC). We examined the solubility of the synthesized polymers in various organic solvents including CHCl3, CH3CN, THF, H2O, CH3OH, DMSO, and DMF and found they are insoluble in both methanol and water. The novolac polymers were evaluated for their photophysical properties and microbial activities. The investigation of the antimicrobial activities of these polymers reveals significant antimicrobial activity against the pathogens E. coli, S. aureus, C. albicans, and A. niger.
The present study reveals the robust and facile methodology for the synthesis of massively selective dispiro-3-phenylpyrrolothiazole hybrids via one-pot 1,3-dipolar cycloaddition reaction by environmentally supported solvents and to evaluate their biological activities. The quaternary ammonium salt eutectic mixture, acetylcholine iodide-ethylene glycol (ACI/EG) medium brings an efficient environment for the synthesis of dispiropyrrolothiazole with excellent yield in shorter reaction time than imidazolium ionic liquids. The eutectic mixture was recovered and reused without any significant drop in their catalytic activity. Among the eight synthesized compounds
4a–h
, halogen derivatives are exhibiting significant antimicrobial activities against selected uropathogens pathogens. Interestingly, chloro and bromo derivatives exhibits the minimum inhibitory concentration (MIC) of 12.5 μg/ml and 6.25 μg/ml towards
Escherichia coli, Klebsiella pneumonia,
and
Staphylococcus aureus
respectively. In addition, the IC
50
values of DPPH radicals with synthesized compounds are interesting, particularly compounds
4a
,
4d
and
4e
shows lower than the control BHA indicating their potent scavenging ability of free radicals.
Electronic supplementary material
The online version of this article (10.1186/s13065-019-0553-3) contains supplementary material, which is available to authorized users.
The fluorescent poly(maleic anhydride-alt-octadecene-arylmethoxypyridine) (PMAOA) and
poly(maleic anhydride-alt-octadecene-arylchloropyridine) (PMAOB) polymers were synthesized and
characterized by FTIR, 1H & 13C NMR spectroscopy. The thermal stability of polymers was measured
by TGA-DTA in the range 100-700 ºC. The fluorescence properties of the synthesized PMAOA and
PMAOB polymers were studied by UV-Vis spectroscopy and fluorescence spectra and showed notable
report due to influence of pyridine grafted to the malelic anhydride ring derivatives. The fluorescent
polymers, PMAOA and PMAOB shows high efficacy of antimicrobial activity against Candida albicans,
Aspergillusniger, Staphylococcus aureus and Escherichia coli pathogens.
The goal of the present study was to copolymerize 3-(4-acetylphenylcarbamoyl) acrylic acid and styrene using azo-bis-isobutyronitrile (AIBN) as a catalyst. The resulting copolymers exhibited number average molecular weights (Mn) of 3.73–5.23 × 104 g/mol with a variable polydispersity (PDI = 2.3–3.8). The amide group of the PMA/PSA polymer was used for grafting poly (-styrene-maleic acid substituted aromatic 2-aminopyridine) by the Hantzsch reaction using a substituted aromatic aldehyde, malononitrile, and ammonium acetate. The polymer can emit strong blue fluorescence (λ = 510 nm) and its thermal stability and solubility were enhanced by polymer grafting. Moreover, the polymer showed the fluorescence spectra of the copolymer had a strong, broad emission band between 300 to 550 nm (maximum wavelength 538 nm) under excitation at 293 nm. The Hantzsch reaction yields an interesting class of nitrogen-based heterocycles that combine with a synthetic strategy for synthesis of grafted co-polymer pyridine-styrene derivatives. The as-prepared pyridine-based polymer compounds were screened against Gram-positive and Gram-negative bacteria, where a maximum inhibition zone toward all four types of bacteria was observed, including specific antifungal activity. Herein, a series of pyridine compounds were synthesized that showed enhanced fluorescent properties and antimicrobial properties due to their unique structure and ability to form polymer assemblies.
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