Smoked cocaine (crack cocaine) causes several forms of injury to the respiratory tract, including asthma exacerbations, lung edema and hemorrhage, and nasal mucosal alterations. Few studies, however, have assessed respiratory tract pathology in habitual users of crack cocaine. Here, we describe the histological alterations in the respiratory tract of mice caused by chronic inhalation of crack cocaine. Twenty 2-month-old BALB/c mice were exposed to the smoke of 5 g crack cocaine in an inhalation chamber once a day for two months and compared to controls (n ¼ 10). We then morphometrically analyzed nose and bronchiolar epithelial alterations, bronchiolar and alveolar macrophage cell density, alveolar hemosiderin content, and in addition determined the vasoconstriction index and the wall thickness of pulmonary arteries. The serum cocaine level was 212.5 ng/mL after a single inhalation. The mucus content of the nasal epithelium increased in crack-exposed animals, and the nasal and bronchial epithelium thickness decreased significantly. The alveolar hemosiderin content and the alveolar and bronchiolar macrophage cell density increased in animals exposed to crack. The vasoconstriction index increased in the pulmonary arteries of the exposed group. Chronic crack cocaine inhalation causes extensive histological changes along the entire respiratory tract.
Este artigo buscou relatar a realização da remoção de uma lesão de hiperplasia fibrosa inflamatória (HFI) localizada em mucosa jugal, sobre região de papila parotídea. Para isso, o indivíduo C.A.C.C., sexo masculino, 56 anos, procurou atendimento na Clínica de Estomatologia do curso de Odontologia da Universidade de Marília – UNIMAR, tendo como queixa principal a sensação de um leve incômodo ao realizar movimentos de fala e mastigação. Então, prosseguiu-se o atendimento com o exame clínico do mesmo e, posteriormente, procedimento cirúrgico de biópsia excisional da massa hiperplásica. Em seguida, a lesão foi submetida ao exame anatomopatológico, com finalidade de confirmação do diagnóstico inicial. Conclui-se, então, ser de extrema importância a promoção da terapêutica adequada ao paciente frente as suas necessidades, uma vez que há obtenção de qualidade de vida, além do descarte da presença de lesões de caráter maligno que possam acometer de forma mais severa o indivíduo.
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