In the present study, aqueous leaf extract of Strobilanthes cordifolia J.R.I.Wood was combined with silver nitrate to synthesis silver nanoparticles (AgNPs). The AgNPs were characterized using visible spectroscopy (UV), X-ray diffraction (XRD), Fourier transform infrared spectrophotometer (FTIR), scanning electron microscope (SEM), energy dispersive X-ray (EDaX), particle size analysis, and transmission electron microscope (TEM). The UV spectrum absorption peak occurred at 438 nm. The FTIR analysis of the AgNPs indicated the presence of functional groups such as aldehyde, alkenes, and carboxylic acids. The crystalline structure of AgNPs was confirmed by XRD. The AgNPs have a spherical shape according to SEM. The AgNPs components composition was confirmed by EDaX. The particle size distribution of AgNPs is monodispersion in the range at 42.54 nm. TEM demonstrated the AgNPs size to be between 11.35 and 34.90 nm. The AgNPs exhibited good antibacterial property against Escherichia coli and Staphylococcus aureus. The antioxidant activity of the AgNPs was represented by increased DPPH, ABTS, and H 2 O 2 activities.The antidiabetic activity of the AgNPs was indicated by the inhibition of α-amylase and α-glycosidase and antiinflammatory highest albumin denaturation and HRBC membrane stabilization properties. Further, the AgNPs also significantly inhibited the MCF-7 cell lines. These results clearly suggest that the synthesized AgNPs using S. cordifolia leaves could have several potential biomedical applications.
To find new sources of antimicrobial and antioxidant agents, methanol extracts of Hardwickia binata Roxb were evaluated systematically. To the present investigation for potential antibacterial and antioxidant phytochemicals in this study and also ADMET and molecular docking for CADD studies. Our results the polyphenol content (total phenol, total flavonoid) and antioxidant capacity of methanol extracts were examined. Identify skin cancer active sites from Hardwickia binata bioactive compounds using GCMS and molecular docking, network pharmacology. The free radical scavenging activities of the methanol extracts also were highest, with the antioxidant activity becoming significantly greater. Furthermore, in vitro antibacterial experiments against phytopathogens such as Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aureginosa validated LE's antimicrobial efficacy. Compared to the other pathogens Enterococcus faecalis have high zone of inhibition (14 ± 0.54). Chemical composition of crude drug extracts was also performed by identify functional groups such as N–H, C–H, OH, and C = O in the methanol extract. GC-MS investigation revealed the existence of 30 bioactive chemicals and 7 active molecules were identify with ADMET and docking in skin cancer proteins (1P7K and 5OTE) among the phytocompounds, Quinoline, 1,2-dihydro-2,2,4-trimethyl (-4.2 kcal/mol; -4.6 kcal/mol), Hexadecanoic acid, methyl ester (-6. kcal/mol; -6.2 kcal/mol) and 5-Phenyl-2,4-pyrimidinediamine, 2TMS derivative (-8.11 kcal/mol; -7.50 kcal/mol) Hardwickia binata is the best compound for the human skin cancer possessed higher binding energy. Our results indicate that the plants can provide sources of natural compounds and the docking studies were carried out in order to predict the most probable kind of interaction, binding affinities, and orientations of the docked ligands at the target protein's active site.
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