A new method for the synthesis of indenone derivatives based on the I2‐promoted cyclization of ortho‐alkynylaryl ketones has been developed. This method provides a metal‐free and convenient route for the regioselective synthesis of indenones using ortho‐alkynylaryl ketones with predefined substituents to give indenone products in moderate to good yields.
A robust synthetic method for the construction of valuable fluorophores, 3-carbonyl-4-arylbenzo[f]indoles and 3-carbonyl-4-arylnaphthofurans, has been developed. The strategy involved a one-pot domino process to achieve the products in moderate to excellent yields.
A divergent synthesis of 3-hydroxyfluorene and 4-azafluorene derivatives has been developed. ortho-Alkynylarylketone was employed as the substrates to react with molecular iodine leading to the generation of a common intermediate, indenone precursor. This precursor could lead to the diversified products when the reaction was carried out under different conditions. The indenone intermediate was converted to the corresponding 3-hydroxyfluorene products under basic conditions while the reaction in the presence of ammonium salt provided 4-azafluorene products. This divergent method could be applied to a broad range of substrates to give the corresponding products in moderate to good yields.
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