:The brain's response to ischemic injury is an acute and long-term inflammatory process. This process involves
activation of resident cells (mainly microglia, hematogenous macrophages), production of proinflammatory mediators and
infiltration of various proinflammatory cells (mainly neutrophils and lymphocytes). These cells play an essential role in
ischemic brain tissue by releasing either proinflammatory or anti-inflammatory mediators at different time points.
However, the exact pathogenesis of proinflammatory or anti-inflammatory genes in this process has not yet been
elucidated. This review aims to investigate the inflammatory process of stroke, especially the role of proinflammatory and
anti-inflammatory genes in the pathogenesis of stroke. We also summarize the current clinical trials of drugs that target
the inflammatory mechanism for intervention.
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