Hydrogen-bonded organic frameworks (HOFs), as an emerging porous material, have attracted increasing research interest in fluorescence sensing due to their inherent fluorescence emission units with unique physicochemical properties. Herein, based on the organic building block 3,3′,5,5′-tetrakis-(4-carboxyphenyl)-1,1′-biphenyl (H4TCBP), the porous material HOF-TCBP was successfully synthesized using hydrogen bond self-assembly in a DMF solution. The fluorescence properties of the HOF-TCBP solution showed that when the concentration was high, excimers were easily formed, the PL emission was red-shifted, and the fluorescence intensity became weaker. HOF-TCBP showed good sensitivity and selectivity to metal ions Fe3+, Cr3+, and anion Cr2O72−. In addition, HOF-TCBP can serve as a label-free fluorescent sensor material for the sensitive and selective detection of dopamine (DA). HOF-based DA sensing is actually easy, low-cost, simple to operate, and highly selective for many potential interfering substances, and it has been successfully applied to the detection of DA in biological samples with satisfactory recoveries (101.1–104.9%). To our knowledge, this is the first report of HOF materials for efficient detection of the neurotransmitter dopamine in biological fluids. In short, this work widely broadens the application of HOF materials as fluorescent sensors for the sensing of ions and biological disease markers.
Design and synthesis of drug delivery carrier for targeted and controlled drug release is very vital but challenging. In this work, based on organic ligand molecule 2,4,6‐tris(4‐carboxyphenyl)aniline (BTB‐NH2), a porous hydrogen‐bonded organic framework material HOF‐BTB‐NH2 was designed and synthesized for targeted drug delivery. The anti‐inflammatory drug Ibuprofen (IBU) was effectively loaded in the HOF‐BTB‐NH2, and it took 6 hours to release IBU completely in PBS buffer solution. This work demonstrates that the porous HOF materials are promising candidates for targeted drug delivery applications.
The highly sensitive detection of carcinogenic pollutant 2,4,6‐trinitrophenol (PA) is of great significance for environmental protection and human health. Based on the organic building block 1,3,6,8‐tetrakis (p‐benzoic acid) pyrene (H4TBAPy), the porous nano‐scale hydrogen‐bonded organic framework material (PFC‐1) was successfully synthesized. The large π‐π conjugated structure makes it to show excellent fluorescence characteristics. PFC‐1 showed excellent selective fluorescence detection for PA. PFC‐1 exhibited significant quenching effect upon the addition of PA. The quenching efficiency Ksv of PFC‐1 material for PA is 9.14×104 M−1 and the limit of detection (LOD) reaches 0.75 μM. PFC‐1 exhibits excellent fluorescence sensing performance for PA, which greatly expands the potential application of hydrogen‐bonded organic framework materials in the field of fluorescence sensing.
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