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The epsilon(4) allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer's disease (LOAD), but LOAD pathology does not all fit neatly around APOE. It is conceivable that genetic variation proximate to APOE contributes to LOAD risk. Therefore, we investigated the degree of linkage disequilibrium (LD) for a comprehensive set of 50 SNPs in and surrounding APOE using a substantial Caucasian sample of 1100 chromosomes. SNPs in APOE were further molecularly haplotyped to determine their phases. One set of SNPs in TOMM40, roughly 15 kb upstream of APOE, showed intriguing LD with the epsilon(4) allele and was strongly associated with the risk for developing LOAD. However, when all the SNPs were entered into a logit model, only the effect of APOE epsilon(4) remained significant. These observations diminish the possibility that loci in the TOMM40 gene may have a major effect on the risk for LOAD in Caucasians.

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We investigate the effect of quantum interference between the two transition pathways from the excited doublet to the ground level of a driven V atom on the spectral features of the resonance fluorescence emission. The ultranarrow spectral line at line center, which arises due to quantum interference, occurs over a wide range of parameters. The smaller the ratio of the excited doublet splitting to the effective Rabi frequency, the more pronounced the spectral line narrowing. However, the fluorescence emission is completely quenched when the atomic dipole moments are exactly parallel and the driving field is tuned to the average frequency of the atomic transitions. The narrow line is due to the slow decay rate of one dressed state, while the quenching arises from dressed-state trapping. A finite laser linewidth destroys the spectral narrowing features and the fluorescence quenching. ͓S1050-2947͑97͒07509-4͔