Collective total synthesis of five tetrahydroisoquinoline alkaloids including the first total synthesis of (−)-fennebricin A and (−)-renieramycin J has been accomplished. The synthesis features employing a single common amino acid to symmetrically construct the pentacycle of title alkaloids. The palladium-catalyzed arylation of alanine-derived amide developed by Yu was tactically utilized to afford unnatural amino acid building block rapidly and practically. The structure of synthetic (−)-renieramycin M has been confirmed by single crystal X-ray analysis for the first time.
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