The success rate of dental implants is limited by peri-implant infection and insufficient osseointegration. Therefore, reducing the occurrence of peri-implantitis and promoting osseointegration are in demand. A roughened surface has commonly been applied to improve the osseointegration of implants, but it will accelerate the attachment of bacteria. We have developed novel antibiotic-decorated titanium (Ti) surfaces by the immobilization of dopamine and cefotaxime sodium (CS) simultaneously. Moreover, the surface roughness of the polydopamine (PDA)/CS coating was controlled by the changes in polymerization times as determined by atomic force microscopy. Then, all antibiotic-grafted Ti surfaces could effectively prevent the adhesion and proliferation of both Escherichia coli and Streptococcus mutans in comparison to the pristine control. For the culture and osteogenic differentiation of human umbilical mesenchymal stem cells (hUMSCs) on the substrate surface, PDA/CS coating with polymerization times less than 30 min showed acceptable biocompatibility, but the upregulation of marker genes and proteins was detected when the polymerization time was more than 30 min. Moreover, the best calcium deposition results were found in the 30 min PDA/CS group with or without the addition of osteogenic factors. Therefore, our PDA/CS coating with a polymerization time of 30 min holds great potential to design dental implants with dual bacteriostatic and osteogenic properties.
At a time when the world is undergoing an unprecedented and dramatic change, strengthening the national spirit of the nation is the key to improving national unity and competitiveness, as well as an important force in uniting the Chinese national spirit. In the course of the development of the Internet, the mechanisms of interethnic interactions among multiple ethnic communities are increasingly enriched and there is a trend towards multidisciplinary and permanent research on ethnic cultural identities, resulting in a constant change in the structure of ethnic interaction and identity networks among ethnic communities. At the same time, the particular perspective and successful application of RMT in the physical realm of reality offers great opportunities for the creation of a complex network of interactions. In this thesis, a matrix of weights is developed for group interaction mechanisms and identity systems of multiple ethnic communities, from which the eigenvalues of the network are identified and matched to the energy spectrum of the random matrix. On this basis, the overall interconnections in real information are investigated in terms of the characteristic spectral density, localized features, and frequency band intervals according to the basic principles of the random matrix. The statistics and analysis of the interaction mechanisms and cognitive concepts of ethnic minority groups in China can visualise and analyse the general ideas, methods, and paths of ethnic cultural identity in China. It can promote communication among ethnic groups, enhance people’s cultural identity, and strengthen China’s cultural cohesion.
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