In view of the photovoltaic grid-connected power system, the transient frequency stability of the system is analyzed in this paper. First, the photovoltaic grid-connected power system was modeled and analyzed. On this basis, the maximum frequency deviation is used as the index to determine the interval in which the system accommodates the maximum photovoltaic capacity, and the influence of frequency stability of the high-permeability photovoltaic high disturbance system is studied. Second, the evaluation and prediction methods of frequency dynamic characteristics of photovoltaic access nodes based on surface fitting are proposed, and the critical values of high penetration photovoltaic access for different grid points are given. Finally, an improvement measure based on the optimization of the frequency modulation parameters of large-capacity units is proposed, and the effectiveness of the proposed method in improving the transient frequency stability of the system after photovoltaic access is verified by the IEEE 39-standard system.
ObjectiveLiver cancer is a significant contributor to global burden of cancer. Transcatheter arterial chemoembolization (TACE) is the standard of care for patients with unresectable liver cancer, and CalliSpheres, as novel drug-eluting bead (DEB) microspheres, have been found to be associated with a high tumor response rate. However, the outcomes after DEB-TACE treatment are not always satisfactory with tumor recurrence. Herein, we attempt to compare the clinical efficacy and safety of DEB-TACE with sorafenib and conventional TACE in treating advanced liver cancer.MethodsThe study retrospectively reviewed clinical records of 96 patients with liver cancer, among which there were 48 cases receiving DEB-TACE with sorafenib and 48 cases receiving conventional TACE. The physical properties of Callispheres were evaluated in HepG2 cells and a B6/J mouse model.ResultsDEB-TACE with Callispheres were demonstrated to effectively maintain stability and prolong the half-life of epirubicin. Compared with the patients receiving conventional TACE, those receiving DEB-TACE with sorafenib exhibited better patient outcomes with increased survival rate, reduced tumor volume, and declined levels of tumor markers. Additionally, DEB-TACE with Callispheres could effectively protect liver function, as well as reduce the toxic effects of loaded epirubicin, and its combination with sorafenib would not increase the incidence of adverse reactions.ConclusionDEB-TACE using CalliSpheres combined with sorafenib could prevent the progression of liver cancer and bring a better prognosis.
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