No abstract

The culprits of atherosclerosis are endothelial damage, local disorders of lipid metabolism, and progressive inflammation. Early atherosclerosis is typically difficult to diagnose in time due to the lack of obvious symptoms, thus missing the best period of treatment. In this work, a π‐conjugated polymer (PMeTPP‐MBT) based on 3,6‐bis(4‐methylthiophen‐2‐yl)‐2,5‐bis(2‐octyldodecyl)pyrrolo[3,4‐c]pyrrole‐1,4(2H,5H)‐dione is designed as a novel photoacoustic contrast agent. On this basis, an intelligent responsive theranostic nanoplatform (PA/ASePSD) combining astaxanthin and SS‐31 peptide and loading with PMeTPP‐MBT is developed. The high affinity between the dextran shell with the broken endothelial surface VCAM‐1 and CD44 confers active targeting of PA/ASePSD to atherosclerotic lesions. High levels of ROS in the acidic plaque microenvironment act as an intelligent cascade switch to achieve controlled release of astaxanthin, SS‐31 peptide, and PMeTPP‐MBT for non‐invasive photoacoustic diagnosis, as well as plaque inhibition mediated by anti‐inflammation and multichannel regulation (including ABCA1, ABCG1, CD36, and LOX‐1) of lipid metabolism. Both in vitro and in vivo evaluations confirm the impressive anti‐atherosclerotic capability and the accurate photoacoustic diagnosis of PA/ASePSD nanoparticles, thus promising a candidate for early‐stage atherosclerosis theranostics.

With the fast development of internet technology, new and large scaled e-commerce enterprises that highly integrate internet technology and financial instruments have rapidly developed in recent years. For these e-commerce enterprises, their daily accounting processing and the structure of external financial statements will be significantly different from the financial statements of traditional enterprises. Therefore, how to understand the financial information of e-commerce enterprise statements in shorten time; how to understand its constituent factors and its significance of financial data; and how to understand the business behavior hidden after financial data, all of which have caught the eyes of the majority of the investors and enterprise managers. Under such social circumstances, the paper taking Alibaba as an example, using DuPont analysis method to conduct a detailed data analysis of Alibaba's overall financial situation through the detailed financial analysis of profitability, operation, solvency, and the financial situation of cash flow. By analyzing the financial situation of profitability, operating capacity, solvency, and cash flow in detail and combining the research methods of corporate financial management and strategy, this paper makes an active exploration for studying the current booming e-commerce enterprises. Through research, this paper demonstrates that Alibaba's good profitability, solvency, and cash flow are stable and are a positive phenomenon and example for both potential investors and business managers. At the same time, through the example of the financial statements, this paper also further discusses the weak links in Alibaba's strategic management, and puts forward reasonable suggestions for the development of related industries.