An imprinted polymer membrane (IPM) with blending trimethoprim-MIP and polysulfone (PSF) was prepared by bulk polymerization and membrane preparation. In the process of the preparation, the influencing factors on membrane structure and properties, such as the concentration of PSF, the content of additive polyethelene glycol (PEG) and TMP imprinted polymer, were thoroughly investigated by scanning electron microscopy (SEM) and the membrane performance tester. The adsorption properties and selectivity properties of IPM to different substrates were estimated by using the method of equilibrium binding experiments. Finally, the transport properties of the membranes were investigated by using the diffusion chambers. The results showed that the imprinted polymer membrane exhibited a high selectivity for TMP.
Using a Zn(II)-quercetin complex as a template (quercetin is a kind of flavonoid; flavonoids are important active ingredients of Chinese herbs), we prepared a new kind of metal coordination imprinted polymer (MCIP) in methanol by a molecular imprinting technique. The coordination mode and coordination ratio between quercetin and Zn(II) were studied in differential ultraviolet absorption spectrometry, and the ternary coordination of quercetin, Zn(II), and 4-vinylpyridine was verified by similar methods. The effect of the crosslinking agent dosage on the morphology and network structure of MCIP and its binding capacity were studied by transmission electron microscopy and equilibrium binding experiments. The regulation of different anions and cations on the identification system of MCIP was studied in detail. In addition, the binding characteristics of MCIP were evaluated by Scatchard analysis. The experimental results show that the Zn(II)-quercetin imprinted polymer had selective binding to its template complex, including selectivities to the anions and cations, and a class of homogeneous recognition sites was formed in the polymer within the range of studied concentration. The dissociation constant and most apparent specific adsorption amount of the Zn(II)-quercetin imprinted polymer was calculated to be 0.6983 mmol/ L and 78.72 lmol/g, respectively.
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