Chemical investigation of the sponge Ircinia formosana resulted in the isolation of seven new linear C22‐sesterterpenoids, irciformonins E–K (1–7) in addition to irciformonin A (8), a previously isolated furanosesterterpenoid (=a furan‐moiety‐containing sesterterpenoid) from the same species. The structures were determined by interpretation of HR‐ESI‐MS and 2D‐NMR spectra. The structure of irciformonin A (8) was revised. Compound 5 exhibited significant inhibition of peripheral blood mononuclear cell proliferation induced by phytohemaglutinin.
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