Perovskite white light-emitting diodes were realized by using a mixture of sky-blue MAPb(Br0.6Cl0.4)3 and orange-red Rhodamine 6G as the emissive layer. The influences of Rhodamine 6G on the properties of...
Organometal halide perovskites are attracting a great deal of attention because of their long carrier diffusion lengths, wide wavelength tunability, and narrow-band emission.
Circulating tumor cell (CTC) test is currently used as a biomarker in cancer treatment. Unfortunately, the poor reproducibility and limited sensitivity with the CTC detection have limited its potential impact on clinical application. A reliable automated CTC detection system is therefore needed. We have designed an automated microfluidic chip-based CTC detection system and hypothesize this novel system can reliably detect CTC from clinical specimens. SKOV3 ovarian cancer cell line was used first to test the reliability of our system. Ten healthy volunteers, 5 patients with benign ovarian tumors, and 8 patients with epithelial ovarian cancer (EOC) were recruited to validate the CTC capturing efficacy in the peripheral blood. The capture rates for spiking test in SKOV3 cells were 48.3% and 89.6% by using anti-EpCAM antibody alone and a combination of anti-EpCAM antibody and anti-N-cadherin antibody, respectively. The system was sensitive to detection of low cell count and showed a linear relationship with the cell counts in our test range. The sensitivity and specificity were 62.5% and 100% when CTC was used as a biomarker for EOC. Our results demonstrated that this automatic CTC platform has a high capture rate and is feasible for detection of CTCs in EOC.
In this study, lead‐free perovskite CsSn(IxBr1−x)3 films with photoluminescence emission wavelengths from 677 to 887 nm are prepared. The influence of air exposure on their characteristics is also investigated. It is found that CsSnI3 can be transformed to Cs2SnI6 upon increasing the air exposure time. The decomposition and oxidation mechanisms are confirmed by the X‐ray diffraction pattern due to the presence of CsI peak. It is observed that devices based on the CsSn(IxBr1−x)3 film with increased Br− ratio and the CsSnI3 film with prolonged air exposure time show inferior performance. These results are mainly attributed to the highest occupied molecular orbital levels of CsSn(IxBr1−x)3 and Cs2SnI6. Defect density of state and binding energy of these materials are also investigated and reported in this study.
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