The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
Respiration, blood pressure, and splanchnic and phrenic discharges were recorded from cats (anesthetized with chloralose, immobilized with Syncurine and artificially ventilated) under conditions of asphyxia, vagotomy, hyperventilation and pneumothorax. The results indicate a close relationship between the vasomotor and respiratory center. Both the respiratory center and ventilation can influence the vasomotor center. The ventilatory influence is exerted through blood pressure changes synchronous with respiration. Although unaffected by decerebration, respiratory grouping of splanchnic discharge was completely abolished by spinal transection at C1, and is probably controlled by the medullary vasomotor center. Since sinus denervation and vagotomy did not abolish respiratory grouping of splanchnic discharge, blood pressure changes can affect the vasomotor center through mechanisms other than sino-aortic reflexes. The difference between positive and negative pressure breathing in effecting the respiratory influence on the vasomotor center is discussed.
NINE FIGURESFor the purpose of studying the higher control of visceral reflexes, the urinary bladder is a convenient organ because its activity can be studied with a simple and quantitative method, cystometry. The resulting cystometrogram is a. curve showing the intravesicular pressure obtained when successive increments of fluid are introduced into the bladder at appropriate intervals. The slope of this pressure-volume curve is an accepted measure of bladder tonus. For the past 70 years since Mosso and Pellacani (1882a, 1882b) introduced the method, most clinical and physiological investigators ( Sherrington, '15 ; '33a, '33b ; Langworthy et al., '33, '40 ; Kolb and Langworthy, '38) have considered bladder tonus, like skeletal muscle tonus, to be under the control of the central nervous system. Recently this concept was seriously challenged by Nesbit et al. ( '47, '48), and Tang and Ruch ( '55) proved that bladder tonus is not due to a reflex and is not even neural in origin, but merely reflects the physical state of the bladder wall.
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