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Background Podoplanin (PDPN) is a glycoprotein associated with epithelial‐mesenchymal transition, invasion, and metastasis in several types of malignancies, including oral and oropharyngeal squamous cell carcinoma (OSCC). The aim of this systematic review (SR) was to summarize and critically appraise the available evidence about the association between PDPN immunoexpression and clinicopathological features and its utility as a prognostic marker in OSCC. Methods Five electronic databases and three gray literature databases were searched for immunohistochemical studies, which were selected in a two‐phase process. Results From 721 records identified, 22 cohort and seven analytical cross‐sectional studies were included. Few studies reported that PDPN expression was associated with poorer survival rates in OSCC: overall survival = 4/12, disease‐free survival = 4/7, and cancer‐specific survival = 2/4 studies. Positive associations were most frequently reported on lymph node involvement, higher histopathological grade, and advanced clinical stages. Conclusion Within limitations of this SR, PDPN may be associated with lymph node involvement, histopathological grade, and clinical stage of OSCC. Current evidence suggests that PDPN could be a useful prognostic marker for OSCC that needs further exploration.

Oral nutritional supplements are widely recommended to head and neck cancer patients undergoing anticancer treatment, however, their effect on outcomes of most importance to patients is unclear. This study aimed to systematically review the evidence of the effect of oral nutritional supplements on mortality, treatment tolerance, quality of life, functional status, body weight, and adverse effects. We searched PubMed, Embase, CENTRAL, LILACS, Web of Science, CINAHL, two trials registry platforms, three sources of grey literature, and reference lists of included studies. We assessed risk of bias using the revised Cochrane risk of bias tool (RoB 2) and certainty of evidence using the GRADE approach. We used random-effects models with Hartung-Knapp correction for the meta-analyses. We included 15 trials, of which 5 were ongoing or unpublished, providing evidence in four comparisons. We found very low to low certainty evidence for the effect of oral nutritional supplements on mortality, treatment tolerance, quality of life, functional status, and adverse effects. When compared to nutritional counselling alone, nutritional counselling plus oral nutritional supplements probably increases body weight slightly. We also found adverse events related to the supplements such as nausea and vomiting, and feeling of fullness. Possible increases in mortality, in treatment tolerance, and in quality of life, besides a possible decrease in functional status, are worth of further investigation. Future research could attempt to address the clinical importance of the probable increase in body weight. Possible adverse effects of the use of oral nutritional supplements should not be overlooked.

Aim To conduct a bibliometric analysis of the top 100 most‐cited papers in dentistry for individuals with neurodevelopmental disorders. Methods and Results A search strategy was constructed and conducted at the Web of Science in the category of “Dentistry, Oral Surgery, and Medicine”. The following information was extracted from each paper: title, authorship, year of publication, title of the journal, study subject, study design, age range of sample participants, type of disability, institution, country and continent, number of citations and citation density. Google Scholar and Scopus were used to crosscheck the number of citations of the most‐cited papers. The VOSviewer software was used to generate bibliometric network maps. The papers received 4453 citations in Web of Science, ranging from 30 to 106 citations. Most papers were published by the USA (35%), had an observational design (78%) and the main subject was epidemiology (31%). Most studies focused on individuals with Down syndrome (34%) and Autism Spectrum Disorder (18%) and were published in the Journal of Periodontology (10%) and the Pediatric Dentistry Journal (7%). Conclusion Most of the studies included in this review were characterized as epidemiological studies. Future research should focus on behavior guidance, dental education, and access to dental services.