A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.
The Front Cover illustrates an efficient protocol for synthesizing polyfunctionalized tetrahydro‐4H‐pyrido[1,2‐b]isoquinolinones. The methodology highlights the power of combining the four‐component Ugi reaction with a xanthate‐based radical cascade process to achieve molecular complexity in a few steps. The cover art features the beautiful library building of the authors’ University in Mexico City and the waterfall in the Basaltic Prisms, Huasca de Ocampo, Hidalgo, Mexico. More information can be found in the Research Article by L. D. Miranda et al.
An efficient protocol for the synthesis of poly‐functionalized 1,2,3,6‐tetrahydro‐4H‐pyrido[1,2‐b]isoquinolin‐4‐ones is described. First, propargyl‐containing Ugi adducts were transformed to polysubstituted dihydroisoquinolines by an intramolecular Au‐catalyzed alkyne hydro‐arylation, followed by the alkene isomerization process. Then, these pivotal intermediates were engaged in a xanthate‐based oxidative radical cascade addition/cyclization process with a suitable alkene.
A simple and efficient method to obtain α-xanthyl ketones from α-diazoketones is described. The reaction proceed through a protonation/nucleophilic substitution sequence with p-toluenesulfonic acid and potassium ethyl xanthogenate as nucleophile. As α-diazoketones can be readily synthesized from ubiquitous carboxylic acids, a broad variety of xanthates can be obtained, including those from natural occurring substrates
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