The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. ?? 2013 Elsevier B.V. All rights reserved

A deep survey of the Large Magellanic Cloud at ∼ 0.1−100 TeV photon energies with the Cherenkov Telescope Array is planned. We assess the detection prospects based on a model for the emission of the galaxy, comprising the four known TeV emitters, mock populations of sources, and interstellar emission on galactic scales. We also assess the detectability of 30 Doradus and SN 1987A, and the constraints that can be derived on the nature of dark matter. The survey will allow for fine spectral studies of N 157B, N 132D, LMC P3, and 30 Doradus C, and half a dozen other sources should be revealed, mainly pulsar-powered objects. The remnant from SN 1987A could be detected if it produces cosmic-ray nuclei with a flat power-law spectrum at high energies, or with a steeper index 2.3 − 2.4 pending a flux increase by a factor > 3 − 4 over ∼ 2015 − 2035. Large-scale interstellar emission remains mostly out of reach of the survey if its > 10 GeV spectrum has a soft photon index ∼ 2.7, but degree-scale 0.1 − 10 TeV pion-decay emission could be detected if the cosmic-ray spectrum hardens above >100 GeV. The 30 Doradus star-forming region is detectable if acceleration efficiency is on the order of 1 − 10% of the mechanical luminosity and diffusion is suppressed by two orders of magnitude within < 100 pc. Finally, the survey could probe the canonical velocity-averaged cross section for self-annihilation of weakly interacting massive particles for cuspy Navarro-Frenk-White profiles.

Background: Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defining CpG islands (CGIs), since all current approaches rely on a large parameter space formed by the thresholds of length, CpG fraction and G+C content.

BackgroundUnmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as main parameters. Recently, clustering methods directly detect clusters of CpG dinucleotides as a statistical property of the genome sequence.ResultsWe compare sliding-window to clustering (i.e. CpGcluster) predictions by applying new ways to detect putative functionality of CpG islands. Analyzing the co-localization with several genomic regions as a function of window size vs. statistical significance (p-value), CpGcluster shows a higher overlap with promoter regions and highly conserved elements, at the same time showing less overlap with Alu retrotransposons. The major difference in the prediction was found for short islands (CpG islets), often exclusively predicted by CpGcluster. Many of these islets seem to be functional, as they are unmethylated, highly conserved and/or located within the promoter region. Finally, we show that window-based islands can spuriously overlap several, differentially regulated promoters as well as different methylation domains, which might indicate a wrong merge of several CpG islands into a single, very long island. The shorter CpGcluster islands seem to be much more specific when concerning the overlap with alternative transcription start sites or the detection of homogenous methylation domains.ConclusionsThe main difference between sliding-window approaches and clustering methods is the length of the predicted islands. Short islands, often differentially methylated, are almost exclusively predicted by CpGcluster. This suggests that CpGcluster may be the algorithm of choice to explore the function of these short, but putatively functional CpG islands.

Aims. We report the first detailed X-ray study of the supernova remnant (SNR) G304.6+0.1, achieved with the XMM-Newton mission. Methods. The powerful imaging capability of XMM-Newton was used to study the X-ray characteristics of the remnant at different energy ranges. The X-ray morphology and spectral properties were analyzed. In addittion, radio and mid-infrared data obtained with the Molonglo Observatory Synthesis Telescope and the Spitzer Space Telescope were used to study the association with the detected X-ray emission and to understand the structure of the SNR at differents wavelengths. Results. The SNR shows an extended and arc-like internal structure in the X-ray band without a compact point-like source inside the remnant. We find a high column density of N H in the range 2.5-3.5 × 10 22 cm −2 , which supports a relatively distant location (d ≥ 9.7 kpc). The X-ray spectrum exhibits at least three emission lines, indicating that the X-ray emission has a thin thermal plasma origin, although a non-thermal contribution cannot be discarded. The spectra of three different regions (north, center and south) are well represented by a combination of a non-equilibrium ionization (PSHOCK) and a power-law (PL) model. The mid-infrared observations show a bright filamentary structure along the north-south direction coincident with the NW radio shell. This suggests that Kes 17 is propagating in a non-uniform environment with high density and that the shock front is interacting with several adjacent massive molecular clouds. The good correspondence of radio and mid-infrared emissions suggests that the filamentary features are caused by shock compression. The X-ray characteristics and well-known radio parameters indicate that G304.6+0.1 is a middle-aged SNR (2.8−6.4) × 10 4 yr old and a new member of the recently proposed group of mixed-morphology SNRs.