PURPOSE: To examine factors associated with completing enrollment milestones in the Together 5,000 cohort of at-risk men (n = 8661), transmen (n = 53), and transwomen (n = 63) who have sex with men. METHODS: Between 2017-2018, participants completed an online enrollment survey and were offered opportunities to complete an incentivized secondary online survey as well as selfadministered at-home HIV testing (OraSure HIV-1 Oral specimen collection device). We explored factors associated with completing each study component. RESULTS: In total, 8,777 individuals completed our enrollment survey, 6,166 (70.3%) completed the secondary survey, and 5,010 returned the at-home HIV test kit that was mailed to them (81.3% of those mailed a kit). Consistent with other researchers, in our multivariable models, those who were White, with more years of education, were more likely to complete study components, although the magnitude of these associations was small. For example, 50.9% of those enrolled, 47.9% of those completing the secondary survey, and 46.8% of those completing HIV testing were persons of color-a statistically significant, but meaningfully insignificant decline. CONCLUSIONS: These findings highlight the ongoing need for researchers to identify barriers that may prevent persons of color and younger individuals from participating in research studies.
Synthesis of novel peptide linkers was accomplished by monocarboxylation of 1,3,5-tris(bomomethyl)benzene with a wide variety of carboxylic acids in the presence of diisopropylethylamine. These reagents can be used to simultaneously cyclize and label peptides containing two cysteines. Many labels are compatible with this method including lipids, fluorescent groups, and biotin.
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