A new heterogeneous nanocatalyst was successfully synthesized, completely characterized and efficiently applied in the synthesis of dihydropyrimidines.
Dihydropyrimidines are synthesized by a one-pot condensation of an aldehyde, b-ketoester and urea or thiourea in the presence of Fe 3 O 4 @camphor as a new heterogeneous magnetic nanocatalyst. The nanospheres morphology of the green natural camphor/ferrite was characterized by Fourier transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM) images, X-ray diffraction (XRD) pattern, energy-dispersive X-ray (EDX), vibrating sample magnetometer (VSM), N 2 adsorption-desorption by Brunauer-Emmett-Teller (BET) and inductively coupled plasma (ICP) analyses. The advantages of this new report are short reaction times, high yields, easy workup, low cost and eco-friendly protocol. The recoverable nanocatalyst was simply prepared and effectively employed for the one-pot multicomponent synthesis of dihydropyrimidine derivatives, for the first time, at room temperature.
In this work, the first synthesis, characterization and catalytic performance of Fe 3 O 4 /camphor core/shell nanospheres as a magnetic composite nanocatalyst were reported. The characterization was carried out by Fourier transform infrared spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, vibrating sample magnetometer, N 2 adsorption-desorption by Brunauer-Emmett-Teller and inductively coupled plasma analyses. The recoverable heterogeneous nanostructure catalyst was simply prepared and effectively employed in the one-pot multicomponent synthesis of b-amino carbonyl compounds in ethanol as a green solvent at room temperature. Further advantages of this new protocol are short reaction times, high yields, easy workup procedure, inexpensive and eco-friendly protocol and magnetically recoverability and several times reusability of the nanocatalyst without significant decrease in catalytic activity.
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