The growth rate of scientific publication has been studied from 1907 to 2007 using available data from a number of literature databases, including Science Citation Index (SCI) and Social Sciences Citation Index (SSCI). Traditional scientific publishing, that is publication in peer-reviewed journals, is still increasing although there are big differences between fields. There are no indications that the growth rate has decreased in the last 50 years. At the same time publication using new channels, for example conference proceedings, open archives and home pages, is growing fast. The growth rate for SCI up to 2007 is smaller than for comparable databases. This means that SCI was covering a decreasing part of the traditional scientific literature. There are also clear indications that the coverage by SCI is especially low in some of the scientific areas with the highest growth rate, including computer science and engineering sciences. The role of conference proceedings, open access archives and publications published on the net is increasing, especially in scientific fields with high growth rates, but this has only partially been reflected in the databases. The new publication channels challenge the use of the big databases in measurements of scientific productivity or output and of the growth rate of science. Because of the declining coverage and this challenge it is problematic that SCI has been used and is used as the dominant source for science indicators based on publication and citation numbers. The limited data available for social sciences show that the growth rate in SSCI was remarkably low and indicate that the coverage by SSCI was declining over time. National Science Indicators from Thomson Reuters is based solely on SCI, SSCI and Arts and Humanities Citation Index (AHCI). Therefore the declining coverage of the citation databases problematizes the use of this source.

With proper patient monitoring, levothyroxine replacement therapy should be effective, inexpensive, and free of complications. Recommendations for thyroid-stimulating hormone suppression with levothyroxine are based on risk-benefit considerations of the biologic characteristics of the thyroid disorder and the individual patient.

Thyroid hormone (T3) binds to a nuclear receptor protein which regulates gene expression by binding to specific DNA sequences near hormone-responsive genes. Proteins encoded by two cellular proto-oncogenes, c-erbA alpha and beta, bind T3 and can act as functional T3 receptors. In rats, alternative splicing of the alpha-gene transcript generates at least two distinct protein products, termed r-erbA alpha 1 and r-erbA alpha 2. Although these proteins bind to the same DNA sequence, r-erbA alpha 2 does not bind T3. We show here that expression of r-erbA alpha 2 inhibits the T3-dependent inductive effect of either r-erbA beta or r-erbA alpha 1 on expression of a T3-responsive test gene. Alternative splicing of the erbA alpha transcript thus generates products with opposing biological activities, suggesting a novel mechanism for the modulation of hormonal responsiveness.

Intraperitoneal administration of hypertonic saline is a potent stimulus to the "stress" responsive hypophysiotrophic parvicellular neurons of the hypothalamic paraventricular nucleus (PVN), as well as to magnocellular neurons of the hypothalamo-neurohypophysial system. Precise identification of the pathways gating information about the "stress" of intraperitoneal hypertonic saline to the PVN has not been ascertained earlier. In this study we demonstrate that intraperitoneal injection of hypertonic saline induces increased expression of c-fos immunoreactivity within neurons of the medial parvicellular division of the PVN, within the circumventricular organs surrounding the anteroventral tip of the third ventricle, and within the magnocellular neurons of the PVN and supraoptic nucleus. Also, neurons involved in conveying visceral information to the PVN, including the parabrachial nucleus, the nucleus of the solitary tract and the ventrolateral medulla responded with increased c-fos expression to the "stress" paradigm. Combined c-fos immunocytochemistry and retrograde tracing experiments with cholera toxin B (ChB) was used to identify neurons projecting to the PVN activated by the applied "stressor." Neither the mere intracerebral presence of ChB nor intraperitoneal administration of isotonic saline influenced the number of c-fos immunoreactive nuclei in the brain. Dual immunocytochemistry revealed that intraperitoneal administration of hypertonic saline induced expression of c-fos immunoreactive nuclei in approximately half of the retrogradely labeled neurons projecting to the PVN from the anteroventral tip of the third ventricle (AV3v), including the subfornical organ (SFO) and the organum vasculosum laminae terminalis (OVLT). In the brainstem, the "stressor" induced expression of c-fos-IR nuclei in almost all of the retrogradely labeled cells of the ventrolateral part of the medulla oblongata (A1 and C1), while only about 25% of the ChB-labeled cells of the caudal part of the nucleus of the solitary tract (A2) were concomitantly immunoreactive to c-fos. Within the parabrachial nucleus, only 20% of the ChB-labeled cells were also immunoreactive for c-fos. The present results provide evidence that information about the "stress" of intraperitoneal hypertonic saline is conveyed to both magnocellular neurons projecting to the neurohypophysis and hypophysiotrophic parvicellular neurons the PVN via afferent projections from a variety of neurons in the osmosensitive anteroventral tip of the third ventricle and visceromotor neurons of the parabrachial nucleus, the ventrolateral medulla and the nucleus of the solitary tract.

Our results indicate that the need for thyroxine increases in many women with primary hypothyroidism when they are pregnant, as reflected by an increase in serum thyrotropin concentrations. Although the effects of this modest level of hypothyroidism are not known, we think it prudent to monitor thyroid function throughout gestation and after delivery and to adjust the thyroxine dose to maintain a normal serum thyrotropin level.

Aims and objectives:To explore how parents and nurses experience partnership in neonatal intensive care units and to identify existing barriers and facilitators to a successful partnership.Background: Family-centred care is recommended as a frame of reference for treatment and care in neonatal intensive care units. A key element in family-centred care is partnership. Such partnerships are characterised by complex interpersonal relationships and interactions between nurses and parents/families. Partnerships therefore appear to present a significant challenge. Design:A qualitative review and meta-synthesis. Methods:Comprehensive searching in ten databases: CINAHL, PubMed (MEDLINE), EMBASE, PsycINFO, Scopus and SweMed+, OpenGrey, MedNar, Google Scholar and ProQuest Dissertations & Thesis Global. A total of 1,644 studies (after removal of duplicates) were critically assessed, and 21 studies fulfilled the inclusion criteria. A meta-aggregation was used to synthesise the findings from the studies and was methodically quality assessed with QUARI/SUMARI and PRISMA.Findings: Through a meta-aggregative approach, two synthesised findings were developed: (a) co-creation of mutual knowledge and (b) developing competencies and negotiating roles. The first synthesis embraced the categories: being respected and listened to, trust and sharing knowledge, and the second synthesis embraced the categories: space to learn with guidance, encouraging and enabling, being in control. In constructing the categories, findings were identified as characteristics, barriers and facilitators to application.

The literature on publication counting demonstrates the use of various terminologies and methods. In many scientific publications, no information at all is given about the counting methods used. There is a lack of knowledge and agreement about the sort of information provided by the various methods, about the theoretical and technical limitations for the different methods and about the size of the differences obtained by using various methods. The need for precise definitions and terminology has been expressed repeatedly but with no success.Counting methods for publications are defined and analysed with the use of set and measure theory. The analysis depends on definitions of basic units for analysis (three chosen for examination), objects of study (three chosen for examination) and score functions (five chosen for examination). The score functions define five classes of counting methods. However, in a number of cases different combinations of basic units of analysis, objects of study and score functions give identical results. Therefore, the result is the characterization of 19 counting methods, five complete counting methods, five complete-normalized counting methods, two whole counting methods, two whole-normalized counting methods, and five straight counting methods.When scores for objects of study are added, the value obtained can be identical with or higher than the score for the union of the objects of study. Therefore, some classes of counting methods, including the classes of complete, complete-normalized and straight counting methods, are additive, others, including the classes of whole and whole-normalized counting methods, are non-additive.An analysis of the differences between scores obtained by different score functions and therefore the differences obtained by different counting methods is presented. In this analysis we introduce a new kind of objects of study, the class of cumulative-turnout networks for objects of study, containing full information on cooperation. Cumulative-turnout networks are all authors, M. GAUFFRIAU et al.: Publication, cooperation and productivity measures 176 Scientometrics 73 (2007) institutions or countries contributing to the publications of an author, an institute or a country. The analysis leads to an interpretation of the results of score functions and to the definition of new indicators for scientific cooperation.We also define a number of other networks, internal cumulative-turnout networks, external cumulative-turnout networks, underlying networks, internal underlying networks and external underlying networks. The networks open new opportunities for quantitative studies of scientific cooperation.

Using a database for publications established at CEST and covering the period from 1981 to 2002 the differences in national scores obtained by different counting methods have been measured. The results are supported by analysing data from the literature. Special attention has been paid to the comparison between the EU and the USA. There are big differences between scores obtained by different methods. In one instance the reduction in scores going from whole to complete-normalized (fractional) counting is 72 per cent. In the literature there is often not enough information given about methods used, and no sign of a clear and consistent terminology and of agreement on properties of and results from different methods. As a matter of fact, whole counting is favourable to certain countries, especially countries with a high level of international cooperation. The problems are increasing with time because of the ever-increasing national and international cooperation in research and the increasing average number of authors per publication. The need for a common understanding and a joint effort to rectify the situation is stressed.