Central giant cell lesion (CGCL) is a reactive bone lesion that occurs mainly in the mandible, characterized by the multinucleated osteoclast-like giant cells in a background of oval to spindle-shaped mononuclear cells. The etiology is unknown and occurs more commonly in young adults. Cherubism, a rare disease found predominantly in females has histologic characteristics indistinguishable from those of CGCL and is caused by mutations mostly present in exon 9 of the SH3BP2 gene. In this study, we investigated four cases of CGCL and one case of cherubism. DNA was extracted from peripheral blood and tumor tissue and all coding and flanking regions of the SH3BP2 amplified by PCR and directly sequenced to identify underlying mutations. Two novel mutations were found; a heterozygous missense mutation c.1442A>T (Q481L) in exon 11 in one sporadic case of CGCL and a heterozygous germline and tumor tissue missense mutation c.320C>T (T107M) in exon 4 in one patient with cherubism. These findings open a new window to investigate the possible relationship between the pathogenesis of the cherubism and CGCL.
Cysticercosis is a condition in which a human acts as the intermediate host of the pork tapeworm Taenia solium. Although cysticercosis is a common disease in some regions of the world and can occur in any body site, oral lesions are rare. This paper reviews the natural history of the disease and reports on seven cases of oral cysticercosis.
These findings show that T(-) in CD28 + 17 (T/C) and the A(+) in CTLA-4 +49 (A/G) genotypes are associated with susceptibility to aggressive periodontal disease. Thus, our study highlights these polymorphisms as potential genetic susceptibility markers of periodontitis in Brazilians.
-Biosolids are residues from the treatment of urban fluids used as a source of nutrients for agricultural and forestry crops. The organic matter contained in this residue and its chemical characteristics may interfere with the behavior of herbicides in the soil. The objective of this study was to evaluate the influence of biosolids on the potential for leaching herbicides mimicking auxin. Two simultaneous experiments were performed: a leaching test of picloram + 2.4-D in soil column with addition of thermally treated biosolids or solarized biosolids and another one to evaluate the effect of leachate application from the leaching tests under inert material. Each type of biosolid was incorporated in sandy soil in the proportions of 0%, 50%, 100% and 150% of the maximum recommended dose for subsurface fertilization for eucalyptus. The soil was conditioned in PVC columns and the herbicide columns based on picloram + 2.4-D (Turuna® Commercial Formulation), corresponding to 240 g L -1 of 2.4-D + 64 g L -1 of picloram at a dose of 3.5 L ha -1 of the commercial product. The columns were submitted to rain simulation and the resulting leachate was collected, followed by its application in sand-filled pots. The Cucumis sativus was sown along the profile of the soil columns and in the pots. The incorporation of the biosolid, independently of the type and dose tested did not interfere in the leaching potential of picloram + 2.4-D. Symptoms of intoxication were observed along all soil columns and pots. Therefore this residue is not very effective for the resolution of environmental problems caused by the leaching of auxin-mimicking herbicides in the soil.
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