Tribulus terrestris has been used in traditional medicine for relieving rheumatic pain and as an analgesic plant for a long time. In this investigation the analgesic effect of methanolic extract of this plant on male albino mice was evaluated by formalin and tail flick test. Extraction of the fruits of the plant was done by two different methods (suxheletion and percolation) with methanol 80%. The percolated extract was injected intraperitoneally in mice at 50, 100, 200, 400, and 800 mg/kg. The results showed that a dose of 100 mg/kg of percolated extract had the highest significant analgesic effect compared to the control group (P < 0.01) in formalin and tail flick test. There is no significant difference in the analgesic effect of suxheleted and percolated extract. The analgesic effect of the extract was lower than morphine, 2.5 mg/kg in both tests, and higher than ASA 300 mg/kg in chronic phase of pain in formalin test (P < 0.05). Pretreatment of animal with naloxone did not change the analgesia induced by the plant extract in both tests, therefore the involvement of opioid receptor in the analgesic effect of this plant was excluded. The results of ulcerogenic studies indicate that the gastric ulcerogenecity of plant extract is lower than the indomethacin in the rat's stomach. It can therefore be concluded that T. terrestris extract has a suitable analgesic effect and further studies are required to produce a more effective product of this plant to substitute for conventional analgesic drugs.

Despite the effectiveness of the standard regimen of magnesium sulfate in the treatment and prevention of eclamptic seizures, it can not provide the proposed therapeutic level of magnesium in all patients. With respect to the lack of correlation between ionized and total magnesium, further studies are necessary to investigate the superiority of measurement of ionized, rather than total magnesium, for titration of therapeutic magnesium sulfate infusion.

Background: Self-medication is a public health concern because of drug misuse/abuse and its medical, social and psychological problems.Aim: Given the growing prevalence of self-medication, the present study aims to determine the prevalence and causes of self-medication among students of Kerman University of Medical Sciences. Method:This cross-sectional study was conducted in 2014 on 550 students who were selected through multistage sampling from Kerman University of Medical Sciences, Kerman, in southeast Iran. Data was collected through a self-report questionnaire. Test-retest reliability and content validity of this questionnaire were confirmed. Data analysis was carried out using descriptive and inferential statistics via t-test and analysis of variance (ANOVA). Results:The prevalence of self-medication among students was 50.2%. The most common cause of self-medication was related to students' knowledge about the diseases and medications (58.7%). The majority of drugs consumed arbitrarily included cough and cold medications (94.5%); analgesics (89.9%); antihistamines (80.0%); herbal drugs and distillates (78.9%); vitamins, minerals, dietary supplements and energizers (71.5%); antibiotics (61.8%); and gastrointestinal drugs (54.9%), respectively. The most common illness that led to self-medication was the common cold (95.4%), and the most important source of information regarding self-medication was the students' own scientific knowledge of medical drugs (80.6%). Conclusion:Due to the adverse effects of self-medication, drug dependency, and microbial resistance and the relatively high prevalence of self-medication among students in this study, it would be advisable to organize awareness campaigns to further educate students about self-medication.

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To permit appropriate targeted therapy, the present clinical study was aimed to investigate the effects of progesterone on the outcome and the serum markers of injury, oxidant activity and inflammation in diffuse axonal injury (DAI). Forty-eight male DAI patients were divided into two groups (control and progesterone). Progesterone group received progesterone in dose of 1mg/kg per 12h for five days. The outcome was investigated using Extended Glasgow Outcome Scale (GOS-E) and functional independence measure (FIM). The markers of inflammation [interleukin-1β (IL-1β), IL-6, transforming growth factor-β1 (TGF-β1)], injury (brain protein of S-100B), and oxidant activity [malondialdehyde (MDA)] were evaluated in the serum of the patients. Higher GOS-E and FIM scores were observed in progesterone group at the six-month follow-up (P<0.05 and P<0.01, respectively). Meanwhile, a reduction in the serum levels of IL-1β, MDA and S-100B was noticed in progesterone group 24h after injury (P<0.05, P<0.001 and P<0.05, respectively), and there was an increase in serum levels of IL-6 and TGF-β1 (P<0.01 and P<0.05, respectively). Also, lower levels of MDA and S-100B, and higher levels of TGF-β1 were observed in progesterone group six days after injury (P<0.05). According to these findings, progesterone may improve the outcome in DAI patients probably through modulation in the levels of cytokines, and reduction in the injury and oxidant activity.

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