Abstract:The aim of this study was to determine the intensity of Hsp27 protein expression in fibrocystic breast changes (FC) and invasive ductal breast carcinoma (IDC) and to examine its impact on patients' clinico-pathological characteristics and overall survival. Immunohistochemical reactions were conducted on archival samples of 20 cases of FC and 101 cases of IDC treated in 1999-2002. Nuclear-cytoplasmic Hsp27 expression was observed in 92 (92.1%) of the examined cases of IDC, and all the cases of FC. Significantly higher Hsp27 expression was observed in G2 (p < 0.01) and G3 cases (p < 0.0001) compared to FC. HER-2 positive cases had higher Hsp27 expression (p = 0.0153), than HER-2 negative cases. Our research showed that Hsp27 could have an impact on tumor malignancy. Moreover, a positive correlation between the expression of Hsp27 and HER-2 positive cases was demonstrated.

Abstract:The aim of this study was to determine the intensity of Hsp27 protein expression in fibrocystic breast changes (FC) and invasive ductal breast carcinoma (IDC) and to examine its impact on patients' clinico-pathological characteristics and overall survival. Immunohistochemical reactions were conducted on archival samples of 20 cases of FC and 101 cases of IDC treated in 1999-2002. Nuclear-cytoplasmic Hsp27 expression was observed in 92 (92.1%) of the examined cases of IDC, and all the cases of FC. Significantly higher Hsp27 expression was observed in G2 (p < 0.01) and G3 cases (p < 0.0001) compared to FC. HER-2 positive cases had higher Hsp27 expression (p = 0.0153), than HER-2 negative cases. Our research showed that Hsp27 could have an impact on tumor malignancy. Moreover, a positive correlation between the expression of Hsp27 and HER-2 positive cases was demonstrated.

Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force. Here, we summarize the most important existing data on the associations between urinary retinol-binding protein 4 and renal diseases and highlight the untapped potential of retinol-binding protein 4 in clinical use.

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Background: Benign prostatic hyperplasia is one of the most common urological diseases. It affects men of all ages, and the incidence increases with age. Due to the location of the prostate in the lower urinary tract area, changes within it can impair urinary function. Early intervention, accurate diagnostics, and appropriate treatment are thus important, especially including conservative methods in the first stage. Aim of the study: The aim of the study was to use and to evaluate the effectiveness of therapeutic massage in benign prostatic hyperplasia.Case report: A course of therapeutic massage was given to a 55-year-old patient diagnosed with benign prostatic hyperplasia. The therapy lasted three weeks, with the procedure being performed twice a week. Each massage lasted twenty minutes and involved manipulation of the lining of the stomach. The patient underwent imaging tests before and after the therapy. On the International Prostate Symptom Score scale, the patient scored 3 points before the therapy and 2 points after it. These results indicate mild symptoms. The level of prostate specific antigen was 1.421 ng/ml. The patient had normal results of uroflowmetry [Qmax 19 ml/s, Qmedium 12 ml/s] both before and after treatment. The urine retention after micturition at both intervals was assessed at about 0 ml. Transrectal ultrasound examination revealed a reduction in prostate volume by about 30% after the therapeutic intervention. Conclusions: The positive effect obtained after therapeutic intervention in the form of the reduced prostate volume in this case shows that massage can serve as a complementary method to reduce BPH symptoms. In the future, it is advisable to continue testing on more patients.