A number
of metathesis reactions were successfully conducted in
4-methyltetrahydropyran, including both standard model dienes, as
well as more complex substrates, such as analogues of biologically
active compounds and active pharmaceutical ingredients. To place this
solvent in a context of pharmaceutical R + D, larger-scale syntheses
of SUAM 1221, a prolyl endopeptidase inhibitor with potential application
in Alzheimer disease treatment, and a derivative of sildenafil, an
analogue of the popular Viagra drug, were executed. In the latter
case, despite all the setup being made in air, the metathesis reaction
at a 33 g scale proceeded very well with relatively low catalyst loading
and without need of aqueous workup or column chromatography.
A simple
strategy for noncovalent immobilization of an olefin metathesis
catalyst inside a (Cr)MIL-101-SO3Na metal–organic
framework (MOF) was presented. The olefin metathesis active corean
alkylidene complex bearing an ammonium-tagged NHC ligand (Apeiron’s
FixCat)was immobilized by ion exchange facilitated by the
use of crown ether. The hybrid material thus obtained was shown with
a number of model substrates to exhibit high activity and selectivity
in a wide range of solvents. Next, selected polyfunctional pharmaceutically
related substrates were transformed using 0.8–0.5 mol % of
the Ru@MOF in polar solvents such as acetone and dimethyl carbonate,
making this technology interesting in the context of green solvent
utilization.
Promoted by homogeneous Ru-benzylidene complexes, the olefin metathesis reaction is a powerful methodology for C-C double bonds formation that can find a number of applications in green chemical production. A set of heterogeneous olefin metathesis pre-catalysts composed of ammonium-tagged Ru-benzylidene complexes 4 (commercial FixCat™ catalyst) and 6 (in-house made) immobilized on solid supports such as 13X zeolite, metal-organic framework (MOF), and SBA-15 silica were obtained and tested in catalysis. These hybrid materials were doped with various amounts of ammonium-tagged styrene derivative 5—a precursor of a spare benzylidene ligand—in order to enhance pre-catalyst regeneration via the so-called release-return “boomerang effect”. Although this effect was for the first time observed inside the solid support, we discovered that non-doped systems gave better results in terms of the resulting turnover number (TON) values, and the most productive were hybrid catalysts composed of 4@MOF, 4@SBA-15, and 6@SBA-15.
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