The main feature of feline coronavirus infection is its manifestation in the form of peritonitis. Feline infectious peritonitis is a highly lethal disease that lacks primary prevention and therapy. Therefore, feline infectious peritonitis is an epizootic problem in the near future. In our review, we demonstrate the current clinical, diagnostic, and therapeutic interventions for feline infectious peritonitis, as well as hypotheses of origin.
Objective: epidemiological analysis of myelodysplastic syndrome, based on the available retrospective data.Materials and methods: a retrospective analysis of the medical history data of 115 patients (61 men and 54 women) with a diagnosis of myelodysplastic syndrome who received treatment in the hematology department of the «City Hospital № 7 of the city of Rostov-on-Don» in the period from 2010 to 2019.Results: the most likely comorbidities were cardiovascular diseases, which are the main cause of sudden death, and endocrine diseases, which together influence the outcome of myelodysplastic syndrome.Conclusions: there are no individual risk assessment algorithms that could determine the goal setting of therapy in patients with myelodysplastic syndrome, whose life expectancy depends more on the course of concomitant diseases.
Coronaviruses (CoVs) pose a huge threat to public health as emerging viruses. Bat-borne CoVs are especially unpredictable in their evolution due to some unique features of bat physiology boosting the rate of mutations in CoVs, which is already high by itself compared to other viruses. Among bats, a meta-analysis of overall CoVs epizootiology identified a nucleic acid observed prevalence of 9.8% (95% CI 8.7–10.9%). The main objectives of our study were to conduct a qPCR screening of CoVs’ prevalence in the insectivorous bat population of Fore-Caucasus and perform their characterization based on the metagenomic NGS of samples with detected CoV RNA. According to the qPCR screening, CoV RNA was detected in 5 samples, resulting in a 3.33% (95% CI 1.1–7.6%) prevalence of CoVs in bats from these studied locations. BetaCoVs reads were identified in raw metagenomic NGS data, however, detailed characterization was not possible due to relatively low RNA concentration in samples. Our results correspond to other studies, although a lower prevalence in qPCR studies was observed compared to other regions and countries. Further studies should require deeper metagenomic NGS investigation, as a supplementary method, which will allow detailed CoV characterization.
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