This volume contains the proceedings of the conference Local and Global Methods in Algebraic Geometry, held from May 12-15, 2016, at the University of Illinois at Chicago, in honor of Lawrence Ein's 60th birthday. The articles cover a broad range of topics in algebraic geometry and related fields, including birational geometry and moduli theory, analytic and positive characteristic methods, geometry of surfaces, singularity theory, hyper-Kähler geometry, rational points, and rational curves. Contents: R. Lazarsfeld, Some remarks on the work of Lawrence Ein; A. Calabri and C. Ciliberto, Contractible curves on a rational surface; F. Catanese, On the canonical map of some surfaces isogenous to a product; C. Ciliberto, F. Flamini, C. Galati, and A. L. Knutsen, Degeneration of differentials and moduli of nodal curves on 3 surfaces; I. Coskun and J. Huizenga, Weak Brill-Noether for rational surfaces; R. Datta and K. E. Smith, Excellence in prime characteristic; M. González Villa, A. Libgober, and L. Maxim, Motivic zeta functions and infinite cyclic covers; C. Hacon, M. Popa, and C. Schnell, Algebraic fiber spaces over abelian varieties: Around a recent theorem by Cao and Păun; S. Ishii and W. Niu, A strongly geometric general residual intersection; J. Kollár, Quadratic solutions of quadratic forms; S. J Kovács, Non-Cohen-Macaulay canonical singularities; N. Mok, Full cones swept out by minimal rational curves on irreducible Hermitian symmetric spaces as examples of varieties underlying geometric substructures; M. Mustaţă and Y. Nakamura, A boundedness conjecture for minimal log discrepancies on a fixed germ; E. Sernesi, The Wahl map of one-nodal curves on K3 surfaces; Y.-T. Siu, Skoda's ideal generation from vanishing theorem for semipositive Nakano curvature and Cauchy-Schwarz inequality for tensors; C. Voisin, Hyper-Kähler compactification of the intermediate Jacobian fibration of a cubic fourfold: The twisted case.