Subclinical hypothyroidism is a very common entity in Indian middle aged population with a prevalence of around 6-15%, dened as increase in
thyroid stimulating hormone (TSH) level without obvious rise in free triiodothyronine (FT3) and free thyroxine (FT4) level. However most of the
patients have an annual conversion of 5% into overt hypothyroidism. Replacement of thyroxine in these patients is always a controversial issue,
deranged lipid prole is an important indication of thyroxine replacement in these patients. In present study which is a case control study, we have
observed improvement in lipid prole after thyroxine replacement in patients of subclinical hypothyroidism with deranged lipid prole. In our
study there is a signicant improvement in total cholesterol, triglyceride, and LDL level without signicant improvement in HDL level after
thyroxine replacement.
With growing epidemic of CAD there is a increase of patients of heart
failure in our country. Inspite of optimal use of ACE inhibitors, beta
blockers, statins (drugs which can alter the natural history of heart
failure) these patients have a gradually downhill course. Advanced
therapy like CRT and implantable debrillation therapy to reduce the
incidence of sudden cardiac death are very costly. Most of the Indian
poor patients can't afford such a costly therapy. Cheap intervention
which can alter the natural history of heart failure are strongly needed.
Most of the Indian patients have low vitamin D level. Low Vitamin D
level have been linked to increase risk of MI, Stroke, CVD mortality
and heart failure.
Background: Dengue is the most widespread mosquito-borne viral infection, found in tropical and subtropical climates worldwide. The World Health Organization has included dengue as one of the 10 threats to global health in 2019 with rapidly evolving epidemiology.
Aims and Objectives: Given the limitation of data in regard to dengue burden, we have planned the present study with the objectives to provide a comprehensive overview of the seroprevalence, clinicoepidemiological profile, and serotype of dengue virus in Agra region of Uttar Pradesh.
Materials and Methods: We conducted an observational study at viral diagnostic and research laboratory, Sarojini Naidu Medical College, Agra, Uttar Pradesh, from August to December 2021. Our study included all blood specimens received at virology laboratory from clinically suspected cases of dengue infection. For the identification of serotype, NS1-positive samples were sent to King Georges Medical University, Lucknow. For clinical-epidemiological profile of dengue positive patients, data were obtained from records of 203 patients from our hospital.
Results: We received total of 5457 serum samples from suspected patients for dengue serology during the study period. In total, positivity rate was 27.29% (1489/5457) and peak of cases was reported in month of October. Median age of dengue positive cases was 17 years. Dengue hemorrhagic fever (DHS) was diagnosed in almost 41% of patients of 203 patients admitted in our hospital. DEN-2 was reported to be most common serotype (97.1%). In our analsyis, we found that in most patients fall in platelets levels below 50,000 happened during the 5th and 6th day in Dengue fever.
Conclusion: We conclude that our study showed higher seroprevalence of dengue in Agra region with the age group of 0–20 years being infected most. DEN-2 was most prevalent circulating strain, which leads to more severe dengue infection.
Diabetic Striatopathy is also a rare complication and also known as
hyperglycemic non-ketotic hemichorea/hemiballism with a
(1)
prevalence of 1 in 100,000 . Present case is a 60 year's old male
referred from a tertiary center with Choreaform movements with
suspicion of caudate nucleus infarct but MRI brain findings suggest
alessknowncomplicationknownasDiabeticStriatopathy
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