Palladium nanoparticles (PdNPs) were used as a catalyst for the one-pot synthesis of a variety of benzofurans by Sonogashira crosscoupling reactions under ambient conditions. The catalyst could be recycled without significant loss in its activity.
We developed an iodine-mediated cascade strategy to synthesize amino pyrazole thioether derivatives (11) in the absence of metals as well as solvents. The present approach provides amino pyrazole thioethers in a highly selective manner without the formation of diaryl sulfide and sulfenyl-enaminonitrile with broad substrate scope. The reactivity of nine sulfenylation sources and synthetic applications of the synthesized compounds have been demonstrated. Thus, the overall iodine-mediated multicomponent reaction (MCR) is more economically feasible, efficient, and environmentally benign.
The present work describes synthesis and photophysical studies of a class of fluorophores containing biologically relevant 1,3-dihydroisobenzofuran scaffold. Ligand-free palladium nanoparticles have been utilized for domino synthesis of 1arylidene-1,3-dihydroisobenzofurans from 2-iodobenzyl alcohol and terminal arylacetylenes under mild reaction conditions. Reaction of terminal alkylacetylenes with 2-iodobenzyl alcohol however, provided only the Sonogashira products (2-(alk-1ynyl)phenyl)methanols. The 1-arylidene-1,3-dihydroisobenzofur-an derivatives showed structured fluorescence spectra in nonpolar cyclohexane, originated from a locally excited state and structureless emission in polar acetonitrile involving intramolecular charge transfer process. The vibronic structures in the locally excited emission were confined to the ring C=C stretching of the dyes. A detailed structure-property relationship of the 1-arylidene-1,3-dihydroisobenzofuran dyes is presented in this study.[a] Dr.
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