93 Background: Male breast cancer is an uncommon disease and the therapy is mainly based on what is know from female breast cancer. Objective: To investigate the clinicopathologic characteristics of male breast cancer and the overall survival in a single institution. Methods: The clinical data and survival status of 75 male breast cancer treated in a Brazilian public cancer hospital from 2000 to 2009 were collected. The association with clinicopathological characteristics and overall survival was analyzed using Kaplan-Meier curves and the Cox proportional hazards regression (enter method) was used to assess survival differences after adjusting for confounders. The study was approved by National Cancer Institute Research and Ethics Committee (number 128/11). Results: The median patient age was 64 years (range 33-86). Estrogen receptor (ER) was positive in 58 (77.3%) patients, while progesterone receptor (PR) were positive in 47 (62.7%). Histology type was ductal infiltrant carcinoma for 57 (76.0%) and 51 (68.0%) patients underwent surgery. The median follow-up period was 43,1 months (range 2.7-147.8). The median survival from the diagnosis of breast cancer was 97.0 months (95%CI 53.6 -140.4) with a 61.7% 5-year overall survival (OS). In the final Cox regression model, independent factors associated with increased risk of death were metastasis at diagnosis (HR = 18.1; 95%CI: 5.9-55.2), ≥ 65 years old (HR = 4.3; 95%CI: 1.7-10.5); tumor stages ≥ IIb (HR = 3.5; 95%CI: 1.3-9.7) and smoking (HR = 1.6; 95%CI: 1.04-2.6). Conclusions: Invasive ductal carcinoma is the main pathologic type. The median survival from the diagnosis of breast cancer was 97.0 months and metastasis at diagnosis, patient age, tumor stage and smoking are independent prognostic factors.
A dor do membro amputado é uma seqüela comum da amputação de um membro do corpo e, até os dias de hoje, a sua etiologia não está totalmente esclarecida. Embora o seu principal mecanismo de ação seja as alterações no Sistema Nervoso Central (SNC), se admite que haja também influência dos mecanismos periféricos e psicológicos. O uso dos adjuvantes, principalmente os antidepressivos tricíclicos (ADT), no tratamento deste tipo de dor crônica, é amplamente realizado, porém sem resultados consistentes ou com comprovação científica. Contudo, o uso dos ADT mostra-se eficaz para tratamento de diversas síndromes álgicas, em parte devido à sua ação central de inibição do transporte neuronal e ao bloqueio do transporte de serotonina nas vias supressoras, fato que antecede o seu mecanismo antidepressivo ou psicotrópico propriamente dito. Este artigo de opinião se destina a propor o uso dos ADT como droga preventiva no tratamento da dor do membro fantasma.
Os autores documentam o caso de um homem de 53 anos, submetido à desarticulação inter-escápulo-torácica direita (técnica de Berger) por neoplasia epitelial maligna em 1993. O paciente desenvolveu quadro de dependência física a opióides, decorrente da tentativa frustrada de tratar a dor do membro fantasma. Após melhor investigação revelou-se que as queixas eram devido à sensação do membro fantasma e dor do coto de amputação, uma vez que o tratamento e o prognóstico são diferentes. Discutem-se as características clínicas da dependência a opióides, a síndrome de abstinência e o uso de metadona nesta situação clínica.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.