Our findings suggest that P. gingivalis HmuY may be associated with increased IL-6 production during CP. Furthermore, patients with periodontitis and individuals with higher HmuY-induced production of IL-6 show a high frequency of the G allele at position -174.

A periodontite é multifatorial e acomete tecidos circundantes dos dentes. Sua etiologia inclui microrganismos como Porphyromonas gingivalis, Tannerella forsythia e Aggregatibacter actinomycetemcomitans. Este trabalho objetivou discutir o papel de Porphyromonas gingivalis na periodontite crônica. Foram pesquisadas as bases eletrônicas PubMed, BIREME e SciELO, buscando aspectos históricos e estudos publicados entre 2000 e 2015, usando, em português e inglês, os descritores: “Periodontite Crônica”, “Porphyromonas gingivalis” e “Fatores de virulência”. Foram encontrados 205 artigos e 24 foram incluídos. Foram selecionados registros sobre doenças periodontais dos primórdios civilizatórios até os dias atuais. Sua prevalência na população mundial permanece alta e diversas pesquisas abordam a etiopatogenia da doença. P. gingivalis é capaz de induzir resposta humoral e celular nos indivíduos infectados. Estudos sobre seus mecanismos de escape e fatores de virulência relatam dano tecidual consequente à resposta imuno-inflamatória exacerbada do hospedeiro que pode evoluir para edentulismo. Estudos da resposta imune a P. gingivalis sugerem seu papel na perpetuação do estado inflamatório por interferir na produção de citocinas e em mecanismos de morte celular em tecidos do hospedeiro, resultando em destruição tecidual. Os conhecimentos atuais sobre mecanismos de infecção e fatores de virulência de P. gingivalis indicam seu papel como componente-chave na periodontite crônica.

Periodontal disease is multifactorial and it affects the tissues surrounding the teeth. Its etiology includes microrganisms as Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans. This work aimed to discuss the role of Porphyromonas gingivalis in chronic periodontitis. The electronic bases PubMed, BIREME and SciELO were used to search for historical aspects and studies published between 2000 and 2015, using the following descriptors in Portuguese and English: “Chronic periodontitis, Porphyromonas gingivalis” and “Virulence factors”. 205 articles were found and 24 were included. Records on periodontal diseases from the early civilization to the present day were found. Its prevalence in the world’s population remains high and several studies report the pathogenesis of the disease. P. gingivalis is able to induce humoral and cellular response in infected individuals. Studies on its escape mechanisms and virulence factors report tissue breakdown consequent to immuno-inflammatory exacerbated response in the host which may evolve into edentulism. Studies of the immune response to P. gingivalis suggest its role in perpetuation of the inflammatory state by interfering with cytokines production and cell death mechanisms in the host’s cells, resulting in tissue destruction. The current knowledge about mechanisms of infection and virulence factors of P. gingivalis indicate its role as a key component in chronic periodontitis.

AssociationbetweenPeriodontitisandSevereAsthmaTheRoleofIgGAntiPorphyromonasgingivalislevels Strictly as per the compliance and regulations of:Abstract-Asthma and periodontitis are both very prevalent worldwide. Although the association between these diseases has been investigated, the biological mechanism underlying this association, especially the role of biological mediators, remains unclear. Thus, the aim of this study was to evaluate serum levels of anti-Porphyromonas gingivalis IgG in subjects with and without severe asthma. A case-control study involving 169 individuals consisted of subjects with severe asthma in addition to others without asthma (control group). An indirect enzyme linked immunosorbent assay (ELISA) was performed to measure serum levels of IgG specific to Porphyromonas gingivalis. Bacterial DNA was extracted from subgingival biofilm samples and real-time polymerase chain reaction (RT-PCR) analysis was performed to quantify Porphyromonas gingivalis levels.Asthma and periodontitis are both very prevalent worldwide. Although the association between these diseases has been investigated, the biological mechanism underlying this association, especially the role of biological mediators, remains unclear. Thus, the aim of this study was to evaluate serum levels of anti-Porphyromonas gingivalis IgG in subjects S Abstract-Author α σ ρ Ѡ: Post graduation Program in Immunology, Federal

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