This study was supported by the Fonds de la Recherche Scientifique-FNRS under Grant n°s 7.4604.16F and 7.6523.18F of Brussels, Belgium, the Fonds Suzanne Duchesne, and Les Amis de l'Institut Bordet. Pauline WAROQUIER was a Grant F.R.S.-FNRS-Télévie of the Fonds de la Recherche Scientifique-FNRS. The authors would like to thank the Commission Communautaire Commune (COCOM) for supporting the intervention. The authors would also like to thank all the participating patients and the breast clinic and radiotherapy teams from the Institut Jules Bordet. The study sponsors served no role in study design, data collection, data analysis, or data interpretation; or in the preparation, review, or report approval.
Objectives
Clinical fear of cancer recurrence (FCR) is highly prevalent among breast cancer patients and appears early in the disease trajectory. A better understanding of psychological factors associated with clinical FCR is essential to guide screening and intervention development. This cross‐sectional study aimed to assess the contribution of attentional bias, intrusive thoughts, metacognitive beliefs, intolerance of uncertainty, thought suppression, and worry to clinical FCR in breast cancer patients in the early survivorship period.
Methods
Seventy‐four patients treated for non‐metastatic breast cancer were enrolled at the end of their treatment. The FCR Inventory‐Short Form (FCRI‐SF) was used to discriminate between the patients with clinical versus nonclinical FCR. Attentional bias to negative and positive cancer‐related and non‐cancer‐related emotional words was assessed with a dot‐probe task. Words were presented for 17, 500, and 1500 ms. Intrusive thoughts and thought suppression were assessed with the White Bear Suppression Inventory, metacognitive beliefs with the Metacognitions Questionnaire‐30, intolerance of uncertainty with the Intolerance of Uncertainty Inventory‐Part A, and worry with the Penn State Worry Questionnaire.
Results
According to univariate analyses, the patients with clinical FCR (FCRI‐SF ≥13) significantly differed from those with nonclinical FCR in terms of intrusive thoughts (p = 0.002), metacognitive beliefs (p = 0.029), intolerance of uncertainty (p < 0.001), and worry (p < 0.001). Intolerance of uncertainty (odds ratio, OR = 1.06; p = 0.040) and worry (OR = 1.09; p = 0.013) remained in the final logistic regression models. All the patients showed vigilance to cancer‐related words, whether with negative or positive valence, at automatic stages of processing (17 ms).
Conclusions
Intolerance of uncertainty and worry were the two psychological factors contributing directly to clinical FCR in our cross‐sectional study. In addition, attentional bias did not differentiate breast cancer patients with clinical versus nonclinical FCR. Treatment approaches for clinical FCR in early survivorship care may need to integrate uncertainty and worry management intervention strategies.
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