Hashimoto (HT) is an autoimmune disease in which destruction of the thyroid occurs as a result of lymphocyte infiltration. It is caused by an increased level of titers of antibody against thyroid peroxidase (TPO) and thyroglobulin (TG). Because of that,in HT patients, changes are observed in the level and metabolism of thyroid hormones, which leads to unspecified physical and psychological symptoms. A high level of antibodies attacking thyroid antigens has been positively correlated with the symptoms. From the etiological point of view, the most important are genetic factors; however, environmental factors are necessary to provoke the immune system to attack until the process is over. Scientists indicate specified stress, toxification, microbiota dysbiosis and under-or over-nutrition, to name only a few. Dietotherapy of Hashimoto's is based on the proper nourishment of the body and regulation of the immune system by an anti-inflammatory diet. Observational and controlled trials have shown frequent nutrition deficiencies in HT patients. In literature, there is evidence for selenium, potassium, iodine, copper, magnesium, zinc, iron, vitamin A, C, D and B. The role of the proper level of protein intake, dietary fibre and unsaturated fatty acids, especially the n-3 family, has been indicated. HT patients should often eliminate lactose because of intolerance and interactions with levothyroxine and gluten because of possible interactions of gliadin with thyroid antigens. The article describes the nutrition factors of HT patients, and share nutrition recommendations for diet therapy.

Introduction and objective.There is a growing interest in a gluten-free diet (GFD) in the management of various autoimmune diseases, including Hashimoto's thyroiditis (HT). Even medical professionals claim that gluten elimination may improve a patient's treatment. Some studies suggest a relationship between gluten intake and HT development or progression. The aim of the study was to analyze and describe available knowledge regarding the effect of gluten or a gluten-free diet on thyroid autoimmunity in HT with or without celiac disease. Brief description of the state of knowledge. Potentially applicable records were obtained through review and analysis of the PUBMED (MEDLINE) and Google Scholar database by using the following phrases: 'hypothyroidism gluten', 'Hashimoto gluten' and 'thyroiditis gluten'. If a record focused on the subject by title and abstrakt, the full paper was screened. Authors' scientific achievements and references of eligible records were screened for possibly omitted studies. The review was focused only on human studies. Discussion. Gluten exclusion might increase the risk of HT development because of the potential nutritional deficiencies related to the low quality of gluten-free products. Gluten intake from crops grown on selenium-depleted soil increases the risk of HT development. Only a few studies suggest that GFD would be beneficial for HT patients, even without the coexistence of CD. The strongest connection between gluten intake and thyroid destruction seems to be based on a mechanism of molecular mimicry between gut and thyroid tissue transglutaminase. Conclusions. Studies conducted so far do not support the claim that HT patients should eliminate gluten from their diet. In view of the limited number of studies, with major limitations and ambiguous results, a gluten-free diet is not recommended.

This review aims to present the importance of nutrients for thyroid health in light of autoimmune Hashimoto's disease. Authors focus mainly on vitamin D and selenium function in the body, metabolism, serum concentration in patients, replenishment outcome after singular or combined the treatment and dose. Vitamin D is essential for immune regulation and yields inflammatory properties. Selenium plays an important role in thyroid metabolism by protecting it from oxidative damage during iodine metabolism and by taking part in thyroid hormone production. Hashimoto is a complex disease and cross-curricular therapies probably will find more interest than oneway therapy.

There is not any diet recommended for Hashimoto’s disease, despite that those patients are often undernourished. Because of the high heterogeneity of Hashimoto’s patients, insight into dietary patterns might shed some light on the patient-tailored dietary approach, thus improving their treatment and helping to identify patients with the highest probability of particular nutritional deficiencies. The aim of this study was to identify Hashimoto’s patients’ dietary patterns and their characterization based on both socio-demographic variables and dietary self-assessment. We collected data online from patients with Hashimoto’s disease. The questionnaire formula used in the study was developed based on a validated food frequency questionnaire KomPAN®. K-means pattern analyses were used to characterize patients into patterns based on the frequency of particular types of foods consumption and socio-demographic factors. Four patterns were identified. We labeled them as ‘Convenient’, ‘Non-meat’, ‘Pro-healthy’, and ‘Carnivores’ with participants proportions at approximately one-fourth per each pattern. The patients were mainly of the female gender (94.08%), with a female: male ratio of 15.9. Hashimoto’s patients differed in their food product choices, food choice motives, dieting experience, nutritional knowledge, smoking habits, food allergies and intolerances, and lipid disorders, and thus represent different eating patterns. However, these patterns were not determined by comorbidities or the majority of ailments.

Introduction and Objective.In the scientific world, the nutritional needs of persons with Hashimoto's autoimmune thyroid disease are discussed, and there is a lot of interest in the autoimmune protocol (AIP). The aim of the study was to check the effects of AIP on thyroid parameters in euthyroid patients with Hashimoto's disease. Materials and method. Among 28 people with Hashimoto's (including 1 male) the consumption of nutrients, anthropometrics, symptoms of the disease, values of thyroid parameters: FT3, FT4, TSH, thyroid ultrasound and autoimmune aTPO, aTG were analyzed before and after 12 weeks of using the AIP diet. The impact of changes in the consumption of selected nutrients on changes in thyroid biochemical parameters were analyzed using multiple regression models, where the dependent variables of the created models were changes in thyroid biochemical parameters. Results. After applying the AIP diet, the number of people reporting symptoms of malaise decreased, the levels of FT3 and FT4 as well as TSH decreased, remaining within the reference concentration range. aTG decreased slightly, but aTPO increased significantly. Ultrasound examination also showed a decrease in the volume of the thyroid gland. The body weight of the subjects decreased, which indicates a caloric deficit. Conclusions. Given the numerous advantages of the AIP diet, extending the observation time of the diet, along with its personalization in terms of food selection, energy and nutritional value, could show changes in both well-being and biochemical test results to a greater extent. The use of a personalized AIP protocol can improve the quality of life, a positive change in mental state, reduction of stress, and above all, the improvement of adverse ailments associated with Hashimoto's disease.