can be upregulated by the myc or ras oncogenes, we also chose to study putative relationships between cyclin D I protein levels and intrinsic cellular sensitivity to CDDP and y-irradiation. We report that in the 16 human cell lines which we have studied, high cyclin DI expression is related to CDDP resistance but has no relationship with radiation responsiveness, whereas high c-raf-I expression, although related to radiosensitivity has no relationship with CDDP responsiveness.

can be upregulated by the myc or ras oncogenes, we also chose to study putative relationships between cyclin D I protein levels and intrinsic cellular sensitivity to CDDP and y-irradiation. We report that in the 16 human cell lines which we have studied, high cyclin DI expression is related to CDDP resistance but has no relationship with radiation responsiveness, whereas high c-raf-I expression, although related to radiosensitivity has no relationship with CDDP responsiveness.