PBM therapy has no deleterious effects on ddMSCs. Although no other clear conclusion was obtained because of the scarce number of publications, the results of these studies are pointing to an important tendency of PBM therapy to improve ddMSCs' viability and proliferation.
ResumoContexto: A população idosa apresenta alta prevalência de hipovitaminose D, sendo provável que, exposta ao uso de anticonvulsivantes, ocorra agravamento dessa condição. Objetivo: Avaliar a interferência do uso crônico de fármacos anticonvulsivantes nos níveis séricos de vitamina D em idosos institucionalizados com idade acima de 65 anos. Métodos: Foram estudados 18 idosos institucionalizados tratados com anticonvulsivantes, por no mínimo 12 meses, comparados a 16 idosos não tratados. Resultados: O estudo demonstrou que os dois grupos cursaram com de ciência de vitamina D, sendo mais pronunciada no grupo tratado com anticonvulsivantes. Embora não houvesse diferença estatisticamente signi cativa nos valores de paratormônio, nos idosos tratados foi observada uma tendência de níveis mais elevados, 53,44 ± 28,92 pg/ml em comparação aos idosos não tratados, 38,5 ± 10,08 pg/ml (P = 0,42). Foi observada diferença estatisticamente signi cativa entre os níveis séricos de 25-hidroxivitamina D nas pacientes do sexo feminino tratadas de 9,22 ± 3,80 ng/ml versus não tratadas, 18,78 ± 7,62 ng/ml (P = 0,03). Conclusão: Nossos achados sugerem que idosos institucionalizados apresentam menores níveis séricos de 25-hidroxivitamina D, con gurando um estado de de ciência, e diferença signi cativa foi detectada nas mulheres tratadas com fármacos anticonvulsivantes. AbstractBackground: Elderly people have a high prevalence of hypovitaminosis D, especially when they are exposed to anticonvulsants. Objective: e present study evaluated the in uence of chronic use of anticonvulsants on serum levels of vitamin D in institutionalized elders aged above 65 years. Methods: Eighteen elderly subjects treated with anticonvulsants were studied for at least 12 months and compared to 16 untreated elders. Results: Vitamin D de ciency was observed in both groups, but the group treated with anticonvulsants showed a more remarkable de ciency. Although there was no statistically signi cant di erence in serum parathyroid hormone levels, elderly patients in treatment had a higher value (53.44 ± 28.92 pg/ml) compared to untreated elders (38.5 ± 10.8 pg/ml: p = 0.42). Statistically signi cant di erence was observed between serum 25-hydroxyvitamin D in treated female patients (9.22 ± 3.80 ng/ml) compared to untreated female patients (18.78 ± 7.62 ng/ml: p = 0.03). Discussion: e observed de ciency in both groups suggests that elderly subjects have lower serum 25-hydroxyvitamin D. Compared to untreated elderly women, elderly women treated with anticonvulsants showed a signi cantly lower serum level of vitamin D.
OBJECTIVE: Supernumerary teeth (ST) are associated with many complications that include tooth impaction, ectopic eruption, and abnormal development of root. The usual treatment is the extraction, although repositioning in the dental arch may sometimes be an alternative. The present study reports the treatment of a case of multiple supernumerary teeth in a non-syndromic patient.CASE DESCRIPTION: A 16-year-old male patient presented two ST in each side of the jaw, detected by panoramic radiography. Syndromes or systemic diseases were not revealed by the anamnesis/ general health history. Cone Beam Computed Tomography (CBCT) showed that the teeth were positioned in the lingual region between the inferior premolars at both right and left sides. Surgical therapy was the treatment of choice, in order to avoid possible eruption.CONCLUSION: An early and accurate diagnosis is extremely important for treatment decision and success, thus avoiding future complications often related to ST.
This translational study evaluated the effect of the direct application of copaiba oil based capping materials on the rat pulp. The biomaterial was analyzed according to inflammatory, repairing and regenerative processes. Class I cavities were prepared on the occlusal surface of the upper and lower molars of Wistar rats (n = 120). Subsequently, standardized cavities was performed with ¼ spherical carbide drill. Pulp exposures were obtained and after their hemostasis with sterile cotton and distilled water, pulp capping was done with application of biomaterials directly on the pulp tissue. The biomaterials used were: COP (Copaíba oil); Ca(OH)2 (calcium hydroxide), Ca(OH)2+COP; MTA (aggregate mineral trioxide); MTA+COP; BIODENTINE (Biodentine®); BIODENTINA+COP. All cavities were restored with temporary cement. The animals were sacrificed after the period of 7, 14, 28 days according to the principles of ethics and animal experimentation. Twenty-one groups were created from the combination of times and materials, each group consisted of 5 animals. The specimens were prepared and processed by histological technique and stained by HE (haemotoxin and eosin); randomized cuts were examined under optical microscope with 100X enlargement by two different examiners. The evaluated criteria were inflammatory and degenerative response, tissue organization, reactive and reparative dentin. In the last experimental period (28 days) of all groups, the surface (mm 2) and the volume (mm 3) of the reactive and reparative dentin formed were analyzed by the high-resolution micro-CT (computerized microtomography) technique. The data were statistically analyzed using the paired T-test, determining the surface and volume of the reparative dentin formed between the experimental groups. In the histological analyzes, the non-parametric Mann-Whitney test was used, comparing groups (α = 5%). BIODENTINE demonstrated a tendency to accelerate the process of pulpal regeneration, initiating the deposition of reparative dentin on the seventh day of the capping. This material had a thicker dentin compared to the other biomaterials. The MTA also demonstrated an efficiency in the formation of the dentin bridge; however, 20% of the samples did not observe the presence of reparative dentin. When adding the COP in these materials, the formation of the dentin bridge was heterogeneous and incomplete, in addition these groups contained an increased inflammatory process. The repair dentin of the Ca(OH)2 group showed a tunnel with a heterogeneous characteristic. The addition of COP to Ca(OH)2 increased dentin formation in the walls around the pulp chamber in 80% of the samples, but this dentin did not show improvement in quality. Thus, pulp cap with COP isolated or associated with Ca(OH)2, MTA and BIODENTINE did not form a complete and homogeneous dentin bridge at the site of pulp exposure.
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