No abstract

Use of a coagulation test-based transfusion algorithm in cardiac surgery patients with abnormal bleeding after CPB reduced non-erythrocyte allogeneic transfusions in the operating room and ICU blood loss.

with other HLA alleles. 4,5,7,8 Furthermore, patients with HLA Susceptibility for type 1 autoimmune hepatitis has DR3 present at an earlier age and enter remission less frebeen associated with the major histocompatibility quently during corticosteroid therapy. 4,6,7 They also relapse alleles DRB1*0301, DRB3*0101, DRB1*0401, and after corticosteroid withdrawal, deteriorate during therapy, DRB4*0103, whereas the DRB1*1501 allele may protect and require liver transplantation more often than patients from the disease. Our aim was to determine if these alwith HLA DR4. 6-10 Because the alleles encompassing DR3 leles or others influence clinical manifestations and and DR4 encode specific amino acid sequences in the DRb prognosis. Eighty-six white patients were evaluated propolypeptide that determine the ability of each class II molespectively for immune features and outcomes. Class I cule to bind and present antigens to T cells, they can directly alleles were determined by microlymphocytotoxicity, influence the immunoreactivities of the effector cells responand class II alleles were assessed by polymerase chain reaction with sequence-specific oligonucleotide probes sible for the disease and, in turn, its clinical expression. 7 or sequence-specific primers. One hundred two white, Current nomenclature of the World Health Organization normal subjects were typed in the same fashion. Patients describes the specific HLA alleles rather than antigens. In with concurrent immunologic diseases were more com-this system, the genetic locus is first identified (i.e., DRB1), monly positive for DRB4*0103 than patients without followed by an asterisk and a four-figure code. The first two these features (68% vs. 38%, P Å .01). DRB1*0301 (86% vs. numbers of the code represent the old allelic group that often 45%, P Å .008) and the DRB1*0301-DRB3*0101 haplotype is equivalent to the serologically defined antigen. Thus, in (79% vs. 42%, P Å .02) occurred more commonly in pa-DRB1*04, the 04 represents DR4. The last two numbers refer tients who deteriorated during corticosteroid therapy. to the allele. Because there are 22 alleles of DR4 in the 1995 In contrast, DRB1*0401 and the DRB1*0401-DRB4*0103 nomenclature report, the DR4 alleles can range from haplotype were associated with a lower frequency of DRB1*0401 to DRB1*0422. 11 death from liver failure or the need for transplantation Recent studies have indicated that DRB1*0301 is the printhan patients with other alleles (0% vs. 37%, P Å .03). cipal risk factor in white patients of northern European exPatients with DRB1*0301 differed from those with traction, that DRB1*0401 has a lesser degree of association, DRB1*0401 in that they were younger and failed treat-and that these two DRB1 alleles are independent markers of ment more commonly (27% vs. 5%, P Å .04). We conclude disease susceptibility. 3,7,12,13 Furthermore, the reported assothat alleles associated with susceptibility to type 1 auto-ciations with DRB3*0101 and DRB4*0103 may arise through immune hepatitis also influence its clinical ...

The need for transfusion is associated with multiple factors, suggesting that a multifaceted, integrated approach may be necessary to reduce this risk.

No abstract

In this case series, we found US-guided percutaneous needle tenotomy followed by PRP injection to be a safe and effective treatment for chronic, recalcitrant tendinopathy, and this treatment was associated with sonographically apparent improvements in tendon morphology. However, because of the intrinsic limitations of the study design and the heterogeneity of treated tendons, further research is required to corroborate our findings.

No abstract

Correlation to plasma hexokinase values and hematocrit interference are the main variables that differentiate glucose meters. Meters that correlate with plasma glucose measured by a reference method over a wide range of glucose concentrations and minimize the effects of hematocrit will allow better glycemic control for critically ill patients.