The aim of this longitudinal study was to describe adherence to evidence-based pressure injury (PI) prevention guidelines in routine clinical practice in Australian hospitals. Data were analysed from four control sites of a larger-cluster randomised trial of a PI intervention. The sample of 799 included 220 (27·5%) Not at risk, 344 (43·1%) At risk and 110 (13·8%) At high risk patients. A total of 84 (10·5%) patients developed a PI during the study: 20 (9·0% of 220) in the Not at risk group, 45 (13·1% of 344) in the At risk group, 15 (13·6% of 110) in the At high risk group and 4 (3·2% of 125) patients who did not have a risk assessment completed. Of all patients, 165 (20·7%) received only one PI prevention strategy, and 494 (61·8%) received ≥2 strategies at some point during the study period. There was no statistical difference in the proportion of time the three risk groups received ≥1 and ≥2 strategies; on average, this was less than half the time they were in the study. Thus, patients were not receiving PI prevention strategies consistently throughout their hospital stay, although it is possible patients' risk changed over the study period.

This study details the synthesis and biological evaluation of a collection of 19 structurally related Minor Groove Binders (MGBs), derived from the natural product distamycin, which were designed to probe antifungal and antimycobacterial activity. From this initial set, we report several MGBs that are worth more detailed investigation and optimisation. MGB-4, MGB-317 and MGB-325 have promising MICs of 2, 4 and 0.25 μg/mL, respectively, against the fungus C. neoformans.MGB-353 and MGB-354 have MICs of 3.1 μM against the mycobacterium M. tuberculosis. The selectivity and activity of these compounds is related to their physicochemical properties and the cell wall/membrane characteristics of the infective agents.

This study explores "Assemblage" thinking as an approach to population geography research. The paper highlights the recent prominence of Assemblage thinking in human geography, before exploring the potential opportunities for engagement by population geographers. In particular, we focus on the production of place as co-constituted by the material (space) and the discursive (knowledge, process, and practice). Considering the Assemblage practice of "Rendering Technical," we reflect on the role that population geography plays in authorising knowledge and supporting policy. This is investigated through a critical taxonomic analysis of recent Scottish demographic data. It is argued on the one hand that this captures key economic and population characteristics of "place," while on the other hand, it offers a limited technical knowledge. We conclude that a reflexive approach to research using Assemblage thinking may challenge the intimate relationship between population geographers and the state.

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Population sustainability is a prevalent yet nebulous concept within academic and policy debates surrounding the nature and consequences of demographic and economic change. This research seeks to add nuance to understandings of population sustainability in ageing societies. The fiscal challenges posed by population ageing mean that more and more states are implementing specific policies in response to it, with limited degrees of success thus far. This investigation examines place-based understandings of population sustainability on the part of local stakeholders in a region of Scotland, a country facing significant demographic challenges and which is enacting policy measures specifically aimed at promoting population sustainability. The findings suggest that the on-the-ground realities of population sustainability are nuanced and complex. As such, there is scope for greater attention to the diversity and complexities of population and economic change at the sub-national scale in broader academic conceptualisations of and policy responses to the increasingly pressing issue of population sustainability.