Oral lichen planus (OLP) is a common, chronic, inflammatory disease of autoimmune origin. The aim of this study is to determine the correlation of the histopathological features with clinical aspects and variants of OLP.
We have retrospectively studied a group of 59 adult patients with confirmed clinical and histopathological diagnosis of OLP from the Oral Pathology Unit of the University of Santiago de Compostela (Spain). Clinical parameters: age, gender, location of the lesions, clinical type, toxic habits, and concomitant treatments were evaluated. Histopathologically, the epithelial response (hyperplasia vs atrophy), presence of ulceration, degree of interface lesion and distribution, intensity, and composition of the inflammatory infiltrate were analyzed.
Patients treated with several systemic drugs had more atrophic/erosive forms of OLP (
P
= .019). Plasma cells were found more commonly in cases showing deep inflammatory involvement of the connective subepithelial tissue than in those where inflammation was only superficially located (
P
<.001). Their presence was also associated with epithelial erosion-ulceration (
P
<.01).
In conclusion, patients treated with several drugs had more atrophic/erosive forms of OLP and frequently associated with a deep specific inflammatory pattern based on plasma cells. Our results could suggest that drug intake by some patients might confer a supplementary aggravating character to the disease, alone or in conjunction with other non-identified factors. More studies should be carried out to confirm this trend and to assess whether this characteristic, can actually influence the evolution of the lesions.
Oral Squamous Cell Carcinomas (OSCC) are one of the most frequent cancers in the world. This term is used to describe malignant tumors of the oral cavity, pharynx and larynx, with a high incidence and mortality. Deregulation of genetic expression is a common process; however, to this we must also add epigenetic modifications, which consist of histone changes, altered expression of miRNAs and aberrant DNA methylation. The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determine the recurrence of the disease and offer new treatment options.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.