The bactericidal activit of oxacilin against ,B-lactamase-hyperproducing strains of Staphylococcus aureus for which the MIC by MicroScan was 1 or 2 ,ug/ml after incubation for 24 h was evaluated by MBC studies and kill kinetics methods. MBC and kil kinetics tests were both performed using Mueler-Hinton broth (MIIB), with and without 2% NaCl supplementation, and incubation at 30 (13,14,17). The use of these detection methods has allowed identification of strains that have been classified ase-resistant penicillin. One way to approach the question of appropriate therapy in the laboratory is bactericidal testing. Therefore, we examined the bactericidal activity of oxacillin against 3-lactamase-hyperproducing strains of S. aureus by determining the MBC. Moreover, because it has been shown that the MBC may not accurately reflect the activity of an antibiotic (18), we also conducted time-kill rate studies. For all tests performed, the effects of 2% NaCl and temperature were examined.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.