We examined hematological parameters for a semifree-ranging population of mandrills to investigate the influence of age and sex, and to establish normative values for age-sex classes. We also investigated the influence of the reproductive cycle on hematological parameters in females and the influence of seasonality on both sexes. We examined hemoglobin concentration, platelet count, white cell count, red cell count, hematocrit, mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), and differential white cell counts, with a total of 459 observations. Red cell counts, hemoglobin, and hematocrit are significantly lower in females than in males, while female white cell counts are significantly higher. Platelet and white cell counts both decreased with age, while MCV and MCHC (males only) increased with age. Absolute lymphocyte counts also decreased with age. Female reproductive status had little effect on hematology, but melengestrol acetate contraceptive implants resulted in significant increases in hemoglobin, white cell count, red cell count, and hematocrit. Finally, lymphocyte counts increased significantly during the wet season in comparison with dry months, which may be related to increased parasite infection during the wet season. We compare our findings to those for other Setchell, Tshipamba, Bourry, Rouquet, Wickings, and Knapp species, and discuss age-sex patterns in light of mandrill life history. Our results demonstrate the importance of including age-sex class, female reproductive status, and season in studies of hematology and will be useful in further studies of the colony.