Intravascular hemolysis began during cardiac surgery under hypothermia in a patient with an anti‐HI cold agglutinin. The hemolysis continued for a week with destruction of an amount of red blood cells equal to the mass of A2B cells transfused. At the same time, 51Cr‐tagged A1 cells were surviving normally. The destruction in vivo of HI positive red blood cells was later duplicated in vitro by pre‐incubating group O red blood cells with the patient's plasma in the cold at a time when he was hematologically normal. This cause of clinical hemolysis must be a rare complication of hypothermia.
437shortly after admission developed chills and fever (40°C). She specifically denied recent insect bites, drug ingestion, or consumption of contaminated foods. She denied sexual contacts, exposure to sick children or adults, and there was no history of surgical or gynaecological manipulations other than the dental procedure one week before the onset of the illness.Physical examination showed a white woman appearing acutely ill rather than chronically ill. Temperature was 40°C, and the pulse rate was 110/min. There were numerous erythematous maculo-papular, papulo-nodular and pustular skin lesions over the extensor surfaces of the distal surfaces of the limbs, and a smaller number over the trunk, back, and buccal mucosa. Several lesions on the extremities had necrotic centres.The right third metacarpophalangeal joint was red, hot, swollen and tender. Large joints, including knees and elbows, were normal. There were no lesions visible in the ocular fundi. The teeth and gums were in good repair although there was heavy tartar on the clinical crown. There was no sign of infection at the site of the recent surgery. Heart sounds were normal with no murmurs. Liver and spleen were not palpable.
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