The efficacy of naproxen in treating rheumatoid arthritis patients was evaluated in a double-blind clinical trial using aspirin as the control drug. The study was conducted at seven centers and involved 80 patients. After an unequivocal increase in disease activity during a drug-free period, patients were randomly assigned to either drug and continued in the trial for 16 weeks. Some patients took low maintenance doses of corticosteroids, or gold salts, or both throughout the trial. Both test drugs significantly decreased disease activity as measured by a number of ways. By objective measurements, naproxen was as effective as aspirin, although patients in the naproxen-treated group entered the trial with more severe disease. By some subjective evaluations, naproxen was considered more effective than aspirin. Although patients taking naproxen had less frequent gastrointestinal side effects and fewer symptoms VIIIth nerve toxicity, the differences were not statistically significant. We conclude that naproxen is a useful addition to the physician's armamentarium for the treatment of rheumatoid arthritis.

A Staged series (n = 25–476} with time data for Bombina orientalis embryonic development is presented. Stages for Bombina and Rana pipiens seem identical except that approximately 50% of opercular closures are symmetrical in Bombina. Counting numbers of embryos at a stage at regular intervals allowed mathematical interpolation of the average time of stage change. A single systematic curve fit the average time per stage of embryonic development, while the increase with time in variance per stage of development was primarily linear. It is possible that the increasing complexity of morphological interstage changes causes increases in the interstage interval and variance per stage over time. The reported method of arriving al a staged series for a previously undocumented species seems more efficient than time-lapse photography. The unusually easy maintenance and dependability or Bombina, contrasting with some amphibians, suggest its use where others have been less practical.

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