Introduction
To estimate the association between the severity of maternal SARS‐CoV2 disease and adversity of maternal and neonatal outcomes.
Methods
A retrospective single‐site descriptive study was conducted, where the records of pregnant women, universally screened for COVID‐19 infection, with laboratory‐confirmed SARS‐CoV2 disease during the period from March 2020 to March 2021 were reviewed. Patients were divided into two groups: an asymptomatic/mild disease group and a moderate/severe disease group. Maternal outcomes, including the incidence of pregnancy‐induced hypertension (PIH)/pre‐eclampsia, cesarean section (CS) rates, maternal intensive care unit (ICU) admission rates, and neonatal outcomes, including preterm birth, low birth weight, and neonatal ICU (NICU) admission rates, were compared in both study groups.
Results
A total of 352 patients were included with 87 (24.7%) having a moderate/severe disease. In this group, the incidence of preterm birth (<37+6 weeks) was 25.3% (n = 22) and that of low birth weight was 23.0% (n = 20) compared to 12.8% (n = 34) and 13.6% (n = 36) respectively in the asymptomatic/mild disease group. The rates of maternal and NICU admissions were also higher in the former group. Moreover, the rates of development of PIH/pre‐eclampsia in the former and latter groups were 9.2% (n = 8) and 4.9% (n = 13), respectively.
Conclusion
There is likely an association between the severity of maternal SARS‐CoV2 disease and adverse maternal and neonatal outcomes.
Sigmoid volvulus is one of the rare causes of intestinal obstruction in pregnancy and can result in significantly increased maternal and fetal mortality rates, especially in the case of delayed diagnosis. In this report, we present a 34-week-pregnant lady presenting with intestinal obstruction due to sigmoid volvulus and her management.
Pheochromocytoma occurs in 1 in every 50,000 hypertensive pregnant lady.
Antenatal diagnosis is critical to reduce maternal and perinatal
mortality rates. Here, we describe a patient diagnosed with
pheochromocytoma at 35 weeks with an atypical presentation of right
flank pain and seizures, her preoperative optimization and intra-partum
surgical management.
Background: Fetal growth restriction (FGR) occurs when a fetus does not attain its genetically assigned expected growth rate. An estimated fetal weight (EFW) or abdominal circumference (AC) below the 10th percentile for gestational age is the ideal definition of this condition.Objectives: This study aimed to compare isosorbide mononitrate and sildenafil citrate therapies in the context of pregnancies complicated by FGR regarding the magnitude of reduction in umbilical artery (UA) Doppler resistance index (RI) in a randomized fashion. Patients and Methods: This research was carried out in the Maternity Hospital of Ain Shams University during the period from March to September 2020. 64 pregnant women with FGR, were recruited from the antenatal clinic. They were subdivided into 2 groups according to a randomization table (Isosorbide mononitrate group versus sildenafil citrate group). Results: The administration of isosorbide mononitrate 30 mg twice daily is as effective as sildenafil citrate 50 mg twice daily in reducing umbilical artery Doppler resistance index (RI), thereby enhancing fetal growth in pregnancies with FGR and in turn reducing the overall perinatal morbidity and mortality caused by iatrogenic prematurity or FGR itself.
Conclusion:We recommend the use of isosorbide mononitrate as a therapeutic agent in pregnancies with FGR caused by placental insufficiency.
Sigmoid volvulus is one of the rare causes of intestinal obstruction in
pregnancy and can result in significantly increased maternal and fetal
mortality rates, especially in case of delayed diagnosis. In this
report, we present a 34 week-pregnant lady presenting with intestinal
obstruction due to sigmoid volvulus and her management.
Pheochromocytoma is one of the rare causes of hypertension in pregnancy, occurring in one in every 50,000 pregnancies. The aim of this case report is to describe an atypical presentation of pheochromocytoma at 35 weeks gestation, where it presented with right flank pain and seizures, its preoperative medical optimization, and intrapartum concurrent surgical management. It also discusses various clinical presentations of pheochromocytoma in pregnancy, appropriate laboratory and radiological investigations, and different modalities of treatment. It is important to consider the possibility of the diagnosis of pheochromocytoma when considering the different causes of high blood pressure in a term pregnancy. Prompt antenatal diagnosis and timely management are critical to reducing maternal and perinatal morbidity and mortality rates.
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