We investigate particle detector responses in some topologically non-trivial spacetimes. We extend a recently proposed regularization of the massless scalar field Wightman function in 4-dimensional Minkowski space to arbitrary dimension, to the massive scalar field, to quotients of Minkowski space under discrete isometry groups and to the massless Dirac field. We investigate in detail the transition rate of inertial and uniformly accelerated detectors on the quotient spaces under groups generated by $(t,x,y,z)\mapsto(t,x,y,z+2a)$, $(t,x,y,z)\mapsto(t,-x,y,z)$, $(t,x,y,z)\mapsto(t,-x,-y,z)$, $(t,x,y,z)\mapsto(t,-x,-y,z+a)$ and some higher dimensional generalizations. For motions in at constant $y$ and $z$ on the latter three spaces the response is time dependent. We also discuss the response of static detectors on the RP^3 geon and inertial detectors on RP^3 de Sitter space via their associated global embedding Minkowski spaces (GEMS). The response on RP^3 de Sitter space, found both directly and in its GEMS, provides support for the validity of applying the GEMS procedure to detector responses and to quotient spaces such as RP^3 de Sitter space and the RP^3 geon where the embedding spaces are Minkowski spaces with suitable identifications.Comment: 47 pages, 9 figure

Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here, we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multi-pixel stimulation of the prosthesis within radiation-safety limits enabled eye tracking in the animals, that they responded to the stimulations in the direction of the implant with repeated saccades, and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of a 378-electrode prosthesis in patients affected by dry atrophic age-related macular degeneration.