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One hundred and two Large White × Landrace Fl hybrid sows were allocated over four parities in a factorial design to two levels of target P2 backfat thickness at parturition (20 mm, F v. 12 mm, T), two levels of lactation feeding {ad libitum, H v. 3 kg/day, L), and two sizes of sucking litter (six v. 10). Sows attained 13 mm P2 when first mated at 126 kg live weight. Fatness (P2, mm) at weaning was significantly influenced by target fatness at parturition (14·2 v. 9·3), lactation feeding level (13·7 v. 10·0), and litter size (12·7 v. 11·0). Changes in backfat (P2, mm) during 28-day lactation were significantly influenced by target fatness at parturition (—5·0 v. —2·5), lactation feeding (-2 0 v. —5·4), and litter size (—2·9 v. -4·6). Sow live weight (kg) at weaning was significantly influenced by target fatness at parturition (211 v. 192), lactation feeding (218 v. 186), and litter size (208 v. 196). Changes in live weight (kg) during 28-day lactation were significantly influenced by target fatness at parturition (—26 v. — 12), lactation feeding (—5 v. —31), and litter size (—12 v. —25). With multiparous sows only, total food intake during 28-day lactation was negatively related to total food intake in pregnancy. Change in backfat (P2, mm) during 28-day lactation = -0·28 - 0·27 P2 at parturition + 0·04 lactation food intake — 0·50 litter size. Change in live weight (kg) during 28-day lactation = -3·8 — 0·15 live weight post partum + 0·36 lactation food intake — 3·3 litter size. Sows with target fat levels of 20 mm P2 at parturition had better food conversion efficiencies than sows with target fat levels of 12 mm. Target fatness at parturition, and especially lactation food intake, but not litter size, significantly influenced the interval (days) from weaning to oestrus in parity 1 (9·1 v. 14·2 and 7·8 v. 15·3, but 11·6 v. 11·5), while n i subsequent parities only litter size influenced the interval (days) from weaning to oestrus (6·0 v. 8·0). Birth weight (kg) of piglets was influenced only marginally by target fatness at parturition (1·4 v. 1·2) in parity 1, and not by the other factors, or in subsequent parities. Piglet growth rate was affected by both target fatness at parturition and litter size, but by lactation feeding level only in the last week of lactation. The relationship between fatness at weaning (mm) and the weaning to oestrus interval (days) for primiparous sows can be expressed as 26·6 — 1·28 P2. High level feeding in lactation imparted production and efficiency benefit in both primiparous and multiparous sows, while pregnancy feeding to a target of 20 mm rather than 12 mm at parturition was of benefit for primiparous sows.

A prospective study of 120 patients newly diagnosed as having Hodgkin's disease and non-Hodgkin's lymphoma was conducted to determine the nature, extent, and timing of the psychiatric and social morbidity associated with the diagnosis and treatment. Patients were interviewed at diagnosis and two, six, and 12 months later by trained interviewers using standardised questionnaires. Psychiatric morbidity was greatest in the three months before treatment, but new episodes of anxiety and depression developed throughout the year of follow up. Altogether 39 patients suffered a depressive illness or anxiety state, or both, and a further 37 experienced borderline anxiety or depression, or both, during the 15 months of assessment. The most common adverse effects of treatment were hair loss, nausea, vomiting, sore mouth, and changes in perception of taste. Toxicity of treatment was associated with psychiatric morbidity. Conditioned responses to chemotherapy were experienced by 32 patients. Social morbidity was low, although difficulties in returning to work and to previous levels of leisure activity were-noted, Although most patients were no longer receiving treatment and were free of disease at the one year follow up, 51 patients continued to complain of loss of energy, 24 of loss of libido, 38 of tiredness, 23 of irritability, 18 of poor concentration, and 23 of memory impairment.These results confirm our retrospective study and suggest that a high price is paid for long term survival by a substantial proportion of patients receiving treatment for Hodgin's disease and non-Hodgkin's lymphoma. IntroductionOur retrospective study suggested that the diagnosis and treatment of Hodgkin's disease and non-Hodgkin's lymphoma were. associated with substantial psychological and social morbidity (see accompanying paper). We therefore conducted a prospective study to determine the exact nature, prevalence, timing, and duration of problems occurring during the first year after diagnosis.

Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and longer t1/2 under both testing situations. When body surface area was used as a covariate, these cross-ethnic differences remained statistically significant (except Cmax) after oral but not IV drug administration. There were no differences between the two Asian groups in any of these parameters examined in this study. These results confirmed previous observations of ethnic differences in the pharmacokinetic response between Asians and Caucasians and suggested that smaller doses of alprazolam may be required for Asians for similar clinical effects as compared to their Caucasian counterparts.