Fire is a common disturbance in the North American boreal forest that influences ecosystem structure and function. The temporal and spatial dynamics of fire are likely to be altered as climate continues to change. In this study, we ask the question: how will area burned in boreal North America by wildfire respond to future changes in climate? To evaluate this question, we developed temporally and spatially explicit relationships between air temperature and fuel moisture codes derived

[1] Recent climatic warming has resulted in pronounced environmental changes in the Arctic, including shrub cover expansion and sea ice shrinkage. These changes foreshadow more dramatic impacts that will occur if the warming trend continues. Among the major challenges in anticipating these impacts are "surprises" stemming from changes in system components that have remained relatively stable in the historic record. Tundra burning is potentially one such component. Here we report paleoecological evidence showing that recent tundra burning is unprecedented in the central Alaskan Arctic within the last 5000 years. Analysis of lake sediment cores reveals peak values of charcoal accumulation corresponding to the Anaktuvuk River Fire in 2007, with no evidence of other fire events throughout the past five millennia in that area. Atmospheric reanalysis suggests that the fire was favored by exceptionally warm and dry weather conditions in summer and early autumn. Boosted regression tree modeling shows that such conditions also explain 95% of the interannual variability in tundra area burned throughout Alaska over the past 60 years and that the response of tundra burning to climatic warming is nonlinear. These results contribute to an emerging body of evidence suggesting that tundra ecosystems can burn more frequently under suitable climatic and fuel conditions. The Anaktuvuk River Fire coincides with extreme sea ice retreat, and tundra area burned in Alaska is moderately correlated with sea ice extent from 1979 to 2009 (r = −0.43, p = 0.02). Recurrences of large tundra fires as a result of sea ice disappearance may represent a novel manifestation of coupled marine-terrestrial responses to climatic warming.

Fire is the keystone disturbance in the Alaskan boreal forest and is highly influenced by summer weather patterns. Records from the last 53 years reveal high variability in the annual area burned in Alaska and corresponding high variability in weather occurring at multiple spatial and temporal scales. Here we use multiple linear regression (MLR) to systematically explore the relationships between weather variables and the annual area burned in Alaska. Variation in the seasonality of the atmospheric circulation-fire linkage is addressed through an evaluation of both the East Pacific teleconnection field and a Pacific Decadal Oscillation index keyed to an annual fire index. In the MLR, seven explanatory variables and an interaction term collectively explain 79% of the variability in the natural logarithm of the number of hectares burned annually by lightning-caused fires in Alaska from 1950 to 2003. Average June temperature alone explains one-third of the variability in the logarithm of annual area burned. The results of this work suggest that the Pacific Decadal Oscillation and the East Pacific teleconnection indices can be useful in determining a priori an estimate of the number of hectares that will burn in an upcoming season. This information also provides insight into the link between ocean-atmosphere interactions and the fire disturbance regime in Alaska.

The boreal forest contains large reserves of carbon. Across this region, wildfires influence the temporal and spatial dynamics of carbon storage. In this study, we estimate fire emissions and changes in carbon storage for boreal North America over the 21st century. We use a gridded data set developed with a multivariate adaptive regression spline approach to determine how area burned varies each year with changing climatic and fuel moisture conditions. We apply the process-based Terrestrial Ecosystem Model to evaluate the role of future fire on the carbon dynamics of boreal North America in the context of changing atmospheric carbon dioxide (CO 2 ) concentration and climate in the A2 and B2 emissions scenarios of the CGCM2 global climate model. Relative to the last decade of the 20th century, decadal total carbon emissions from fire increase by 2.5-4.4 times by 2091-2100, depending on the climate scenario and assumptions about CO 2 fertilization. Larger fire emissions occur with warmer climates or if CO 2 fertilization is assumed to occur. Despite the increases in fire emissions, our simulations indicate that boreal North America will be a carbon sink over the 21st century if CO 2 fertilization is assumed to occur in the future. In contrast, simulations excluding CO 2 fertilization over the same period indicate that the region will change to a carbon source to the atmosphere, with the source being 2.1 times greater under the warmer A2 scenario than the B2 scenario. To improve estimates of wildfire on terrestrial carbon dynamics in boreal North America, future studies should incorporate the role of dynamic vegetation to represent more accurately post-fire successional processes, incorporate fire severity parameters that change in time and space, account for human influences through increased fire suppression, and integrate the role of other disturbances and their interactions with future fire regime.

Boreal forests and arctic tundra cover 33% of global land area and store an estimated 50% of total soil carbon. Because wildfire is a key driver of terrestrial carbon cycling, increasing fire activity in these ecosystems would likely have global implications. To anticipate potential spatiotemporal variability in fire‐regime shifts, we modeled the spatially explicit 30‐yr probability of fire occurrence as a function of climate and landscape features (i.e. vegetation and topography) across Alaska. Boosted regression tree (BRT) models captured the spatial distribution of fire across boreal forest and tundra ecoregions (AUC from 0.63–0.78 and Pearson correlations between predicted and observed data from 0.54–0.71), highlighting summer temperature and annual moisture availability as the most influential controls of historical fire regimes. Modeled fire–climate relationships revealed distinct thresholds to fire occurrence, with a nonlinear increase in the probability of fire above an average July temperature of 13.4°C and below an annual moisture availability (i.e. P‐PET) of approximately 150 mm. To anticipate potential fire‐regime responses to 21st‐century climate change, we informed our BRTs with Coupled Model Intercomparison Project Phase 5 climate projections under the RCP 6.0 scenario. Based on these projected climatic changes alone (i.e. not accounting for potential changes in vegetation), our results suggest an increasing probability of wildfire in Alaskan boreal forest and tundra ecosystems, but of varying magnitude across space and throughout the 21st century. Regions with historically low flammability, including tundra and the forest–tundra boundary, are particularly vulnerable to climatically induced changes in fire activity, with up to a fourfold increase in the 30‐yr probability of fire occurrence by 2100. Our results underscore the climatic potential for novel fire regimes to develop in these ecosystems, relative to the past 6000–35 000 yr, and spatial variability in the vulnerability of wildfire regimes and associated ecological processes to 21st‐century climate change.

Anthropogenic climate change may result in novel disturbances to Arctic tundra ecosystems. Understanding the natural variability of tundra‐fire regimes and their linkages to climate is essential in evaluating whether tundra burning has increased in recent years. Historical observations and charcoal records from lake sediments reveal a wide range of fire regimes in Arctic tundra, with fire‐return intervals varying from decades to millennia. Analysis of historical data shows strong climate–fire relationships, with threshold effects of summer temperature and precipitation. Projections based on 21st‐century climate scenarios suggest that annual area burned will approximately double in Alaskan tundra by the end of the century. Fires can release ancient carbon from tundra ecosystems and catalyze other biogeochemical and biophysical changes, with local to global consequences. Given the increased likelihood of tundra burning in coming decades, land managers and policy makers need to consider the ecological and socioeconomic impacts of fire in the Far North.

Unprecedented developments in stem cell research herald a new era of hope and expectation for novel therapies. However, they also present a major challenge for regulators since safety assessment criteria, designed for conventional agents, are largely inappropriate for cell-based therapies. This article aims to set out the safety issues pertaining to novel stem cell-derived treatments, to identify knowledge gaps that require further research, and to suggest a roadmap for developing safety assessment criteria. It is essential that regulators, pharmaceutical providers, and safety scientists work together to frame new safety guidelines, based on "acceptable risk," so that patients are adequately protected but the safety "bar" is not set so high that exciting new treatments are lost.

A synthesis was carried out to examine Alaska’s boreal forest fire regime. During the 2000s, an average of 767 000 ha·year–1 burned, 50% higher than in any previous decade since the 1940s. Over the past 60 years, there was a decrease in the number of lightning-ignited fires, an increase in extreme lightning-ignited fire events, an increase in human-ignited fires, and a decrease in the number of extreme human-ignited fire events. The fraction of area burned from human-ignited fires fell from 26% for the 1950s and 1960s to 5% for the 1990s and 2000s, a result from the change in fire policy that gave the highest suppression priorities to fire events that occurred near human settlements. The amount of area burned during late-season fires increased over the past two decades. Deeper burning of surface organic layers in black spruce ( Picea mariana (Mill.) BSP) forests occurred during late-growing-season fires and on more well-drained sites. These trends all point to black spruce forests becoming increasingly vulnerable to the combined changes of key characteristics of Alaska’s fire regime, except on poorly drained sites, which are resistant to deep burning. The implications of these fire regime changes to the vulnerability and resilience of Alaska’s boreal forests and land and fire management are discussed.