Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been recognized as potent antioxidant agents. Since SGLT2i are nephroprotective drugs, we aimed to examine the urine antioxidant status in patients with type 2 diabetes mellitus (T2DM). One hundred and one subjects participated in this study, including 37 T2DM patients treated with SGLT2i, 31 T2DM patients not using SGLT2i, and 33 healthy individuals serving as a control group. Total antioxidant capacity (TAC), superoxide dismutase (SOD), manganese superoxide dismutase (MnSOD), free thiol groups (R-SH, sulfhydryl groups), and catalase (CAT) activity, as well as glucose concentration, were assessed in the urine of all participants. Urine SOD and MnSOD activity were significantly higher among T2DM patients treated with SGLT2i than T2DM patients without SGLT2i treatment ( p = 0.009 and p = 0.003 , respectively) and to the healthy controls ( p = 0.002 and p = 0.001 , respectively). TAC was significantly lower in patients with T2DM treated with SGLT2i when compared to those not treated and healthy subjects ( p = 0.036 and p = 0.019 , respectively). It could be hypothesized that the mechanism by which SGLT2i provides nephroprotective effects involves improvement of the SOD antioxidant activity. However, lower TAC might impose higher OS (oxidative stress), and elevation of SOD activity might be a compensatory mechanism.
Cel pracyStały wzrost zachorowań na cukrzycę skłania do poszukiwań nowszych form leczenia, ale także do badań różnych czynników mających wpływ na jakość życia tych pacjentów. Celem pracy była ocena związku wybranych parametrów stanu psychicznego z jakością życia pacjentów z cukrzycą.MetodaBadaniem objęto 51 pacjentów z cukrzycą typu 1 i 52 pacjentów z cukrzycą typu 2. W badaniach wykorzystano skale: jakości życia SF-36, AIS, HADS oraz SWLS.WynikiPacjenci z cukrzycą typu 2 osiągnęli niższe wartości niż pacjenci z cukrzycą typu 1 jedynie w zakresie funkcjonowania fizycznego skali SF-36 (p=0.001). Oceniając związek między parametrami badanymi wykazano, że długość trwania choroby wiązała się z gorszą oceną ogólnego stanu zdrowia (p=0.036) wśród pacjentów z cukrzycą typu 1. Natomiast wśród pacjentów z cukrzycą typu 2 czas trwania choroby korelował ujemny z funkcjonowaniem fizycznym (p=0.002), fizycznym funkcjonowaniem w rolach społecznych (p=0.001) i bólem fizycznym (p=0.047) a także satysfakcją z życia (p=0.012) a dodatnio z wartościami hemoglobiny glikowanej ( p=0,04). Wśród pacjentów z cukrzycą typu 1 poziom depresji ujemnie korelował z poziomem akceptacji choroby (p= 0.0009) oraz satysfakcją z życia (p=0.006), natomiast poziom lęku jedynie z poziomem akceptacji choroby (p=0.0004) a większe nasilenie lęku wiązało się z gorszą kontrolą metaboliczną (p= 0, 02). W grupie pacjentów z cukrzycą typu 2 poziom lęku korelował negatywnie z poziomem akceptacji choroby (p=0.003).WnioskiZ powodu licznych ograniczeń, jakie niesie ze sobą przewlekła choroba, należy zwracać większą uwagę na aspekt jakości życia oraz stan psychiczny pacjentów z rozpoznaniem cukrzycy oraz włączyć ocenę powyższych parametrów do procesu terapeutycznego.
Aim: The aim of this study was to evaluate health-promoting behaviors as a factor supporting life satisfaction and a protective factor against stress in a group of Polish medical students during the third wave of the SARS-CoV-2 pandemic. Material: The study was conducted in October–December 2021. There were 306 people, including 203 students in the 1st year of medicine, aged 20.42 ± 1.92 years, and 103 students in the 5th year of medicine, aged 24.88 ± 1.7 years. Methods: The following were used: the Satisfaction with Life Scale (SWLS), the Health Behavior Inventory (IZZ), and the Perceived Stress Scale (PSS-10). The survey was conducted online. Results: In the study group, the average result of 23.66 ± 5.97 was obtained in the life satisfaction questionnaire. In the overall assessment of health behaviors (IZZ), an average score of 80.06 ± 13.81 points was obtained. In the PSS-10 questionnaire, the respondents obtained an average of 21.10 ± 5.89 points. There were significant, negative correlations between the results obtained in the health behavior inventory with the results obtained in the stress scale and positive correlations with the results obtained in the life satisfaction scale. Moreover, in the assessment of the influence of prohealth behavior parameters on perceived stress and life satisfaction, a positive effect of PMA on life satisfaction was demonstrated, as well as a protective effect of Positive Mental Attitude (PMA) and Prohealth Activities (PhA) in relation to stress. Conclusions: Life in the period of the third wave of the pandemic was assessed by medical students as moderately satisfactory. Significant intensity of stress negatively correlated with life satisfaction. Health-promoting behaviors, and especially positive mental attitudes, seem to play a protective role in stressful situations and improve life satisfaction.
Purpose The fear for health, uncertainty, loss of freedom, boredom, and frustration accompanying the COVID-19 pandemic caused mental health burdens. Young people are particularly at a risk of emotional functioning problems. The aim of this manuscript was to verify the relationships between health behaviors and emotional functioning in health sciences students during the third wave of the COVID-19 pandemic in Poland. Patients and Methods The study group comprised 493 Polish health sciences students (314 women, 179 men) aged 21.5 ± 2.25 years. The intensity of health behaviors was examined using the Health Behavior Inventory (HBI). The Hospital Anxiety and Depression Scale (HADS) was carried out to assess symptoms of anxiety and depression. Stress levels were examined with the Perceived Stress Scale (PSS-10). The online versions of psychological scales were created using Google Forms software. Results Mild anxiety symptoms were observed in 21% of examined students and moderate-to-severe in 28%. Mild depressive symptoms were observed in 14% of the study group, and 8% of the examined students suffered from moderate-to-severe depression. The mean perceived stress result was high (22.2 ± 4.1 pts.). The overall intensity of health behavior was, at the mean level, significantly higher in females compared to males. The odds of developing severe symptoms in terms of anxiety, depression, and stress in students with high levels of health-related behaviors were respectively: four times, more than seven times, and nine times lower compared to students with lower levels of these behaviors. Conclusion Undertaking regular pro-health behavior decreased the odds of developing severe symptoms of anxiety, depression, and stress in health sciences students during the COVID-19 pandemic.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.